The opioid crisis has stimulated renewed interest in analgesic drug development. This effort
will involve preclinical-to-clinical translational research and will benefit from a focus on …

Pain is a major cause of distress, both physical and psychological and is also associated
with increased inpatient hospital stays, poor wound healing and prolonged rehabilitation …

Background: Assessing analgesic drugs developed over preceding 50 years demonstrated
that very intensive efforts directed at diverse molecular pain targets produced thousands of …

Abstract Purpose of Review Opioid use and abuse has led to a worldwide opioid epidemic.
And while opioids are clinically useful when appropriately indicated, they are associated …

Pain remains a major factor in patients seeking physician assistance. Neither the NSAIDs
(non-steroidal, anti-inflammatory drugs) nor the opioids represent a complete answer to pain …

The pharmacological treatment of chronic pain is generally hampered by a limited clinical
outcome. Hence, there is a strong need for new therapeutic concepts considering the …

There are many obstacles for the development of effective medications to treat chronic pain,
including the inherent challenges in identifying pathophysiological mechanisms, the overlap …

Over the last thirty years, the concern of Pain Medicine practitioners about the potential for
their patients to develop a dependence on opioids has left opioid therapy as a largely …

Unrelieved pain has major negative effects on the lives of millions of people worldwide, and
is associated with huge societal costs. Breakthroughs in pain therapy have been rare in the …