Pharmacological treatments for chronic pain are limited in options and effectiveness, 29 with
only about half of patients experiencing a 30% reduction in pain intensity. 25 In light of …

Opioid-related death and overdose have now reached epidemic proportions. In response to
this public health crisis, the National Institutes of Health (NIH) launched the Helping to End …

Introduction: Opioids are the oldest and most potent drugs for the treatment of severe pain,
but they are burdened by detrimental side effects such as respiratory depression, addiction …

Pain is a common phenomenon that is expressed due to external tissue injury or innate
physiological dysfunction. While everyone has experienced pain in some form or the other …

The review by Tallarida in this issue is noteworthy for two reasons. It marks the first of a new
type of review for the journal. We all have benefited from the careful and thorough major …

Existing treatments for neuropathic pain deliver inadequate pain relief, unacceptable side
effects, or both. The unmet medical need for more effective treatment is driving a large …

As many as 50 million people in the United States suffer from chronic pain. 1 Our most
effective analgesics—including opioids, nonsteroidal anti‐inflammatory drugs …

Opioid misuse and addiction are a public health crisis resulting in debilitation, deaths, and
significant social and economic impact. Curbing this crisis requires collaboration among …

Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians
giving pain relief in any clinical setting, describing the pharmacologic principles and clinical …