Oxidative stress has been recognized as the contributor to diabetic peripheral neuropathy
(DPN). Antioxidant strategies have been most widely explored; nevertheless, whether …

Diabetic peripheral neuropathy (DPN) is one of the most common and debilitating
microvascular complications of diabetes, and there is no effective therapy for the prevention …

Salvianolic acid A (SalA) is one of the main efficacious, water-soluble constituents of Salvia
miltiorrhiza Bunge. This study investigated the protective effects of SalA on peripheral nerve …

Objectives The aim of this study was to evaluate the neuroprotective effects of SalB on high
glucose (HG)-induced excessive autophagy and apoptosis in vitro. Methods The …

Oxidative stress is considered a major contributor in the pathogenesis of diabetic
neuropathy and in diabetes complications, such as nephropathy and cardiovascular …

Diabetic peripheral neuropathy (DPN) is caused by hyperglycemia, which induces oxidative
stress and inflammatory responses that damage nerve tissue. Excessive generation of …

Ethnopharmacological relevance Paeoniflorin (PF) is the principal bioactive component of
Paeonia lactiflora Pall., which an included in Tang Luo Ning recipe, a traditional Chinese …

Oxidative stress and mitochondrial dysfunction are considered to be major contributing
factors in the development and progression of many neurodegenerative diseases …

Background Salvianolate lyophilized injection (SLI) has been clinically used in China for the
treatment of acutely cerebral infarction. Clinical and experimental studies have shown that …

Reactive oxygen intermediates production and apoptotic damage induced by high glucose
are major causes of neuronal damage in diabetic neuropathy. Berberine (BBR), a natural …