[HTML][HTML] Knockdown of sestrin2 increases pro-inflammatory reactions and ER stress in the endothelium via an AMPK dependent mechanism
HJ Hwang, TW Jung, JH Choi, HJ Lee… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Abstract Background & Objective Sestrin2 (sesn2) has recently gained attention as an
important regulator for various metabolic disorders. Sesn2 is involved in AMP-activated …
important regulator for various metabolic disorders. Sesn2 is involved in AMP-activated …
Upregulation of sestrin-2 expression protects against endothelial toxicity of angiotensin II
L Yi, F Li, Y Yong, D Jianting, Z Liting… - Cell Biology and …, 2014 - Springer
Abstract Sestrin-2 (SESN2) is involved in the cellular response to different stress conditions.
However, the function of SESN2 in the cardiovascular system remains unknown. In the …
However, the function of SESN2 in the cardiovascular system remains unknown. In the …
[HTML][HTML] Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress
Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to
endothelial cell dysfunction, a hallmark of cardiovascular diseases, in close interplay with …
endothelial cell dysfunction, a hallmark of cardiovascular diseases, in close interplay with …
SESN1 attenuates the Ox‑LDL‑induced inflammation, apoptosis and endothelial‑mesenchymal transition of human umbilical vein endothelial cells by regulating …
F Gao, Y Zhao, B Zhang, C Xiao… - Molecular …, 2022 - spandidos-publications.com
Endothelial cells are an important component of the heart and vasculature and form a crucial
link between the cardiovascular system and the immune system. Sestrin 1 (SESN1) has an …
link between the cardiovascular system and the immune system. Sestrin 1 (SESN1) has an …
Knockdown of Sestrin2 Increases Lipopolysaccharide‐Induced Oxidative Stress, Apoptosis, and Fibrotic Reactions in H9c2 Cells and Heart Tissues of Mice via an …
HJ Hwang, JW Kim, HS Chung, JA Seo… - Mediators of …, 2018 - Wiley Online Library
Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for
its potential to treat various inflammatory diseases. However, the relationship of sesn2 with …
its potential to treat various inflammatory diseases. However, the relationship of sesn2 with …
The protective role of Sestrin2 in atherosclerotic and cardiac diseases
Y Kishimoto, K Kondo, Y Momiyama - International Journal of Molecular …, 2021 - mdpi.com
Atherosclerotic disease, such as coronary artery disease (CAD), is known to be a chronic
inflammatory disease, as well as an age-related disease. Excessive oxidative stress …
inflammatory disease, as well as an age-related disease. Excessive oxidative stress …
Upregulation of Sestrin2 expression protects against macrophage apoptosis induced by oxidized low-density lipoprotein
HJ Hu, ZY Shi, XL Lin, SM Chen, QY Wang… - DNA and Cell …, 2015 - liebertpub.com
Sestrin2 is involved in a different cellular response to stress conditions. However, the
function of Sestrin2 in the cardiovascular system remains unknown. In the present study, we …
function of Sestrin2 in the cardiovascular system remains unknown. In the present study, we …
Sestrin2 increases in aortas and plasma from aortic dissection patients and alleviates angiotensin II-induced smooth muscle cell apoptosis via the Nrf2 pathway
T Xiao, L Zhang, Y Huang, Y Shi, J Wang, Q Ji, J Ye… - Life Sciences, 2019 - Elsevier
Background Previous studies have demonstrated that oxidative stress is closely related to
aortic dissection (AD). Sestrin2 (Sesn2) is an important antioxidant protein, and this study …
aortic dissection (AD). Sestrin2 (Sesn2) is an important antioxidant protein, and this study …
Sestrin1 inhibits oxidized low‐density lipoprotein‐induced activation of NLRP3 inflammasome in macrophages in a murine atherosclerosis model
Y Keping, S Yunfeng, X Pengzhuo… - European Journal of …, 2020 - Wiley Online Library
Macrophages play a crucial role in the progression of atherosclerotic lesions. In the current
study, we analyzed the expression and function of sestrin1 (SESN1) in the aorta …
study, we analyzed the expression and function of sestrin1 (SESN1) in the aorta …
Regulatory mechanisms of Sesn2 and its role in multi-organ diseases
S Wang, M Xiao, J Zhang, Y Guo, Y Tang, J Gu - Pharmacological …, 2021 - Elsevier
Abstract Sestrin2 (Sesn2) is a powerful anti-oxidant that can prevent acute and chronic
diseases. The role of Sesn2 has been thoroughly reviewed in liver, nervous system, and …
diseases. The role of Sesn2 has been thoroughly reviewed in liver, nervous system, and …