JAK2 genetic variants are associated with inflammatory bowel disease (IBD) and JAK
inhibitors are being evaluated for therapy targeting immune-mediated diseases, including …

JAK1 is a critical effector of pro-inflammatory cytokine signaling and plays important roles in
immune function, while abnormal JAK1 activity has been linked to immunological and …

Jak3, one of the four members comprising the Jak family of cytosolic tyrosine kinases, has
emerged as a promising target for nontoxic immunotherapies. Although a number of Jak …

Purpose Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine
receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are …

Autoinflammatory disease can result from monogenic errors of immunity. We describe a
patient with early-onset multi-organ immune dysregulation resulting from a mosaic, gain-of …

Cytokines are critical in regulating the development and function of diverse cells. Janus
kinase 3 (Jak3) is a tyrosine kinase expressed in hematopoietic cells that associates with the …

Abstract Janus tyrosine kinase 2 (JAK2) mediates downstream signaling of cytokine
receptors in all hematological lineages, yet constitutively active JAK2 mutants are able to …

Given the importance of Jak2 in cell signaling, a critical role for Jak2 in immune cells
especially dendritic cells (DCs) has long been proposed. The exact function for Jak2 in DCs …

The JAK2 V617F variant constitutes a genetic alteration of higher frequency in BCR/ABL1
negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G˃ T …

Purpose The aetiology of intestinal barrier dysfunction in Crohn's disease (CD) is poorly
understood. Associations in relatives of CD families suggest a genetic basis, but the relevant …