JAK2 disease-risk variants are gain of function and JAK signaling threshold determines innate receptor-induced proinflammatory cytokine secretion in macrophages
M Hedl, DD Proctor, C Abraham - The Journal of Immunology, 2016 - journals.aai.org
JAK2 genetic variants are associated with inflammatory bowel disease (IBD) and JAK
inhibitors are being evaluated for therapy targeting immune-mediated diseases, including …
inhibitors are being evaluated for therapy targeting immune-mediated diseases, including …
[HTML][HTML] Jak1 integrates cytokine sensing to regulate hematopoietic stem cell function and stress hematopoiesis
JAK1 is a critical effector of pro-inflammatory cytokine signaling and plays important roles in
immune function, while abnormal JAK1 activity has been linked to immunological and …
immune function, while abnormal JAK1 activity has been linked to immunological and …
[HTML][HTML] Specific Jak3 downregulation in lymphocytes impairs γc cytokine signal transduction and alleviates antigen-driven inflammation in vivo
AG Gómez-Valadés, M Llamas, S Blanch… - … Therapy-Nucleic Acids, 2012 - cell.com
Jak3, one of the four members comprising the Jak family of cytosolic tyrosine kinases, has
emerged as a promising target for nontoxic immunotherapies. Although a number of Jak …
emerged as a promising target for nontoxic immunotherapies. Although a number of Jak …
[HTML][HTML] Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria
V Daza-Cajigal, AS Albuquerque, DF Young… - Frontiers in …, 2022 - frontiersin.org
Purpose Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine
receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are …
receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are …
[HTML][HTML] Complex autoinflammatory syndrome unveils fundamental principles of JAK1 kinase transcriptional and biochemical function
Autoinflammatory disease can result from monogenic errors of immunity. We describe a
patient with early-onset multi-organ immune dysregulation resulting from a mosaic, gain-of …
patient with early-onset multi-organ immune dysregulation resulting from a mosaic, gain-of …
Jak3 negatively regulates dendritic-cell cytokine production and survival
Cytokines are critical in regulating the development and function of diverse cells. Janus
kinase 3 (Jak3) is a tyrosine kinase expressed in hematopoietic cells that associates with the …
kinase 3 (Jak3) is a tyrosine kinase expressed in hematopoietic cells that associates with the …
Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm
H Yao, Y Ma, Z Hong, L Zhao, SA Monaghan, MC Hu… - Leukemia, 2017 - nature.com
Abstract Janus tyrosine kinase 2 (JAK2) mediates downstream signaling of cytokine
receptors in all hematological lineages, yet constitutively active JAK2 mutants are able to …
receptors in all hematological lineages, yet constitutively active JAK2 mutants are able to …
[HTML][HTML] Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock
J Zhong, P Yang, K Muta, R Dong, M Marrero, F Gong… - PLoS …, 2010 - journals.plos.org
Given the importance of Jak2 in cell signaling, a critical role for Jak2 in immune cells
especially dendritic cells (DCs) has long been proposed. The exact function for Jak2 in DCs …
especially dendritic cells (DCs) has long been proposed. The exact function for Jak2 in DCs …
[HTML][HTML] JAK2 Variant Signaling: Genetic, Hematologic and Immune Implication in Chronic Myeloproliferative Neoplasms
DG Torres, J Paes, AG da Costa, A Malheiro, GV Silva… - Biomolecules, 2022 - mdpi.com
The JAK2 V617F variant constitutes a genetic alteration of higher frequency in BCR/ABL1
negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G˃ T …
negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G˃ T …
The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action
M Prager, J Büttner, V Haas, DC Baumgart… - International journal of …, 2012 - Springer
Purpose The aetiology of intestinal barrier dysfunction in Crohn's disease (CD) is poorly
understood. Associations in relatives of CD families suggest a genetic basis, but the relevant …
understood. Associations in relatives of CD families suggest a genetic basis, but the relevant …