Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes
Abstract Background Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal
transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate …
transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate …
Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance
Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of chronic liver
disease and is now considered to be the hepatic manifestation of the metabolic syndrome …
disease and is now considered to be the hepatic manifestation of the metabolic syndrome …
Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis
Janus kinase 3 (Jak3) is a nonreceptor tyrosine kinase expressed in both hematopoietic and
nonhematopoietic cells. Previously, we characterized the functions of Jak3 in cytoskeletal …
nonhematopoietic cells. Previously, we characterized the functions of Jak3 in cytoskeletal …
Janus kinase 3 (JAK3): a critical conserved node in immunity disrupted in immune cell cancer and immunodeficiency
C Liongue, T Ratnayake, F Basheer… - International Journal of …, 2024 - mdpi.com
The Janus kinase (JAK) family is a small group of protein tyrosine kinases that represent a
central component of intracellular signaling downstream from a myriad of cytokine receptors …
central component of intracellular signaling downstream from a myriad of cytokine receptors …
Activation of Janus kinase signaling pathway in acne lesions
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway has been linked to the pathogenesis of many inflammatory skin diseases; however …
pathway has been linked to the pathogenesis of many inflammatory skin diseases; however …
Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent
Z Li, M Gakovic, J Ragimbeau, ML Eloranta… - The Journal of …, 2013 - journals.aai.org
Tyk2 belongs to the Janus protein tyrosine kinase family and is involved in signaling of
immunoregulatory cytokines (type I and III IFNs, IL-6, IL-10, and IL-12 families) via its …
immunoregulatory cytokines (type I and III IFNs, IL-6, IL-10, and IL-12 families) via its …
[HTML][HTML] Immunohistochemistry of Janus kinase 1 (JAK1) expression in vitiligo
Background Vitiligo is a chronic autoimmune disease in which the destruction of
melanocytes causes white spots on the affected skin. Janus kinase (JAK) is a family of …
melanocytes causes white spots on the affected skin. Janus kinase (JAK) is a family of …
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
C Xue, Q Yao, X Gu, Q Shi, X Yuan, Q Chu… - Signal transduction and …, 2023 - nature.com
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
The role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cells
The role of JAK-3 in TLR-mediated innate immune responses is poorly understood, although
the suppressive function of JAK3 inhibition in adaptive immune response has been well …
the suppressive function of JAK3 inhibition in adaptive immune response has been well …
JAK inhibitors and oxidative stress control
A Charras, P Arvaniti, C Le Dantec… - Frontiers in …, 2019 - frontiersin.org
Primary Sjögren's syndrome (SjS) is a complex autoimmune epithelitis, with few treatment
options, but the use of Janus kinase (JAK) inhibitors is promising because suppression of …
options, but the use of Janus kinase (JAK) inhibitors is promising because suppression of …