A network-based pharmacology study of the herb-induced liver injury potential of traditional hepatoprotective Chinese herbal medicines

M Hong, S Li, HY Tan, F Cheung, N Wang, J Huang… - Molecules, 2017 - mdpi.com
Herbal medicines are widely used for treating liver diseases and generally regarded as safe
due to their extensive use in Traditional Chinese Medicine practice for thousands of years …

Study on the mechanism of Mongolian medicine Herba Lomatognii against acute liver injury based on network pharmacology.

M Ao, M Bao, Y Hou, Y Yue, H Li… - Journal of Chinese …, 2023 - search.ebscohost.com
In the present study, we aimed to study the action mechanism of Mongolian medicine Herba
Lomatognii on acute liver injury (ALI) using network pharmacology and bioinformatics …

Network Pharmacology Approach to Explore the Potential Mechanisms of Jieduan‐Niwan Formula Treating Acute‐on‐Chronic Liver Failure

J Liang, M Wu, C Bai, C Ma, P Fang… - Evidence‐Based …, 2020 - Wiley Online Library
Background. Acute‐on‐chronic liver failure (ACLF) is a clinical syndrome with acute
jaundice and coagulation dysfunction caused by various inducements on the basis of …

Hepatoprotective effects of a functional formula of three Chinese medicinal herbs: experimental evidence and network pharmacology-based identification of …

S Li, N Wang, M Hong, HY Tan, G Pan, Y Feng - Molecules, 2018 - mdpi.com
Various Chinese herbal medicines (CHMs) have shown beneficial liver protection effects.
Jian-Gan-Bao (JGB), a functional herbal formula, consists of three famous CHMs, including …

Study on the potential molecular mechanism of xihuang pill in the treatment of pancreatic cancer based on network pharmacology and bioinformatics

J Wang, Y Zhang, Q Wang, L Wang… - Evidence‐Based …, 2022 - Wiley Online Library
Objective. We aimed to analyze the possible molecular mechanism of Xihuang pill (XHP) in
the treatment of pancreatic cancer based on methods of network pharmacology, molecular …

Protective effect of Tibetan medicine Qiwei Tiexie pills on liver injury induced by acetaminophen overdose: An integrated strategy of network pharmacology …

X Bian, L Chen, X Bian, L Li, D Liu, S Liu, L Xu, X Huo… - Phytomedicine, 2024 - Elsevier
Background Drug-induced liver injury, particularly from acetaminophen (APAP), has
emerged as a significant public health concern. Unfortunately, there is currently no effective …

The Protective Effect of Panax notoginseng Mixture on Hepatic Ischemia/Reperfusion Injury in Mice via Regulating NR3C2, SRC, and GAPDH

W Hou, B Wei, HS Liu - Frontiers in Pharmacology, 2021 - frontiersin.org
Panax notoginseng mixture (PNM) has the characteristics of multicomponent, multitarget,
and multieffect, which can cope with the multidirectional and multidimensional complex …

Potential hepatotoxic compounds and mechanisms of Epimedii folium based on network toxicology and cell experimental validation

L Zhang, T Wang, ZY Xu, S Yang, P Li - Zhongguo Zhong yao za zhi …, 2021 - europepmc.org
To probe the potential hepatotoxic components of Epimedii Folium and investigate its
mechanism based on network toxicology and cell experimental validation. According to the …

Integrating network pharmacology and pharmacological evaluation for deciphering the action mechanism of herbal formula zuojin pill in suppressing hepatocellular …

W Guo, J Huang, N Wang, HY Tan, F Cheung… - Frontiers in …, 2019 - frontiersin.org
Hepatocellular carcinoma (HCC) is a kind of complicated disease with an increasing
incidence all over the world. A classic Chinese medicine formula, Zuojin pill (ZJP), was …

Deciphering the underlying mechanisms of formula le-cao-shi against liver injuries by integrating network pharmacology, metabonomics, and experimental validation

Q Zhao, X Ren, SY Song, RL Yu, X Li… - Frontiers in …, 2022 - frontiersin.org
Le-Cao-Shi (LCS) has long been used as a folk traditional Chinese medicine formula
against liver injuries, whereas its pharmacological mechanisms remain elusive. Our study …