Recent advances in gossypol derivatives and analogs: a chemistry and biology view
Y Lu, J Li, CE Dong, J Huang, HB Zhou… - Future Medicinal …, 2017 - Taylor & Francis
Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic
contexts for a long time. The chemical modifications on gossypol were limited due to the …
contexts for a long time. The chemical modifications on gossypol were limited due to the …
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design
Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases
Despite the vast amounts of research and remarkable discoveries that have been made in
recent decades, cancer remains a leading cause of death and a major public health concern …
recent decades, cancer remains a leading cause of death and a major public health concern …
Natural product gossypol and its derivatives in precision cancer medicine
Gossypol, a natural product extracted from the seed, roots, and stem of cotton, was initially
used as a male contraceptive but was subsequently investigated as a novel antitumor agent …
used as a male contraceptive but was subsequently investigated as a novel antitumor agent …
The potential roles of gossypol as anticancer agent: advances and future directions
D Paunovic, J Rajkovic, R Novakovic… - Chinese Medicine, 2023 - Springer
Gossypol, a polyphenolic aldehyde derived from cottonseed plants, has seen a
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
Therapeutic potential of gossypol: an overview
H Keshmiri-Neghab, B Goliaei - Pharmaceutical Biology, 2014 - Taylor & Francis
Context: Polyphenols are naturally occurring compounds found in fruits, vegetables, cereals,
and beverages. Polyphenols occupy a unique place in biological science for their …
and beverages. Polyphenols occupy a unique place in biological science for their …
Investigations on gossypol: past and present developments
K Dodou - Expert opinion on investigational drugs, 2005 - Taylor & Francis
Gossypol has received significant attention as a result of its potential therapeutic application
as a male antifertility agent. Furthermore, recent research examining the biological activity of …
as a male antifertility agent. Furthermore, recent research examining the biological activity of …
Gossypin: a flavonoid with diverse pharmacological effects
B Song, X Shen, C Tong, S Zhang… - Chemical Biology & …, 2023 - Wiley Online Library
Gossypin is a flavonoid compound prepared from chinese medicine Hibiscus, which not only
has significant pharmacological activities in antioxidant, anti‐inflammatory, neuroprotective …
has significant pharmacological activities in antioxidant, anti‐inflammatory, neuroprotective …
Reaction chemistry of gossypol and its derivatives
JA Kenar - Journal of the American Oil Chemists' Society, 2006 - Wiley Online Library
Gossypol, a complex polyphenolic compound, is a naturally occurring highly colored yellow
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …
Novel O-glycosidic gossypol isomers and their bioactivities
J Yin, L Jin, F Chen, X Wang, A Kitaygorodskiy… - Carbohydrate …, 2011 - Elsevier
Novel glycosidic gossypol analogs, 7, 7′-gossypol diglucoside tetraacetate GS1, 6, 7′-
gossypol diglucoside tetraacetate GS2, 7, 7′-gossypol diglycoside GS1′, 6, 7′-gossypol …
gossypol diglucoside tetraacetate GS2, 7, 7′-gossypol diglycoside GS1′, 6, 7′-gossypol …