Structurally simplified zaragozic acid (squalestatin): Stereoselective preparation of a 3, 4-unsubstituted derivative

H Ito, M Matsumoto, T Yoshizawa, K Takao… - Tetrahedron letters, 1997 - Elsevier
Stereoselective preparation of a structurally simplified 3, 4-unsubstituted zaragozic acid
derivative was achieved starting from D-glucose. The present approach involved the …

Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer

P Kovacic - Current medicinal chemistry, 2003 - ingentaconnect.com
Gossypol, a constituent of cottonseeds, displays various drug properties, including
antifertility and anticancer. Toxicity is shown against the reproductive system, heart, liver …

Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant–gossypol

P Przybylski, K Pyta, J Stefańska… - European journal of …, 2009 - Elsevier
Using Gossypol (GOS) extracted from cotton seeds, a series of its Schiff bases (1–18) and
hydrazones (19–27) have been synthesized and evaluated for their antimicrobial activities …

Naturally active oligostilbenes

XF Wang, CS Yao - Journal of Asian natural products research, 2016 - Taylor & Francis
Many naturally occurring oligostilbenes have drawn considerable attention because of their
intricate structures and diverse biological activities. In recent years, oligostilbene …

Pharmacological properties and derivatives of saikosaponins—a review of recent studies

Y Zhu, Y Lai - Journal of Pharmacy and Pharmacology, 2023 - academic.oup.com
Abstract Objectives Saikosaponins (SSs) constitute a class of medicinal monomers
characterised by a triterpene tricyclic structure. Despite their potential therapeutic effects for …

[PDF][PDF] Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers.

CC Benz, MA Keniry, JM Ford, AJ Townsend… - Molecular …, 1990 - Citeseer
Racemic gossypol has been shown to have antitumor properties that may be due to its
ability to uncouple tumor mitochondria or to its inhibitory effects on a variety of …

Strychnine and its mono-and dimeric analogues: a pharmaco-chemical perspective

DP Zlotos, YM Mandour, AA Jensen - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to November 2021 Since its isolation in 1818, strychnine has attracted the
attention of a plethora of chemists and pharmacologists who have established its structure …

The synthesis of (S)-(+)-gossypol via an asymmetric Ullmann coupling

JJ Willemsen - Chemical Communications, 1997 - pubs.rsc.org
The synthesis of (S)-(+)-gossypol via an asymmetric Ullmann coupling Page 1 OMe OMe Pri
R1O O OR2 OMe N O But OMe OMe Pri OMe OMe OMe OMe R Pri OMe OMe N O Me Me R X …

An efficient synthesis of gougerotin and related analogues using solid-and solution-phase methodology

MT Migawa, LM Risen, RH Griffey, EE Swayze - Organic Letters, 2005 - ACS Publications
The first solid-phase synthesis of the natural product gougerotin has been accomplished.
The synthetic route is versatile and allows for diversification at position C-4 of the …

Research progress on the pharmacological effects and molecular mechanisms of pinostrobin

Z Wang, J Zhao, Y Chen, G Liu… - Natural Product …, 2023 - journals.sagepub.com
Pinostrobin (5-hydroxy-7-methoxyflavanone) is an active flavonoid substance. It is widely
present in many traditional Chinese herbs, including Carya cathayensis leaves …