It is well known that spirostane-type saponins show various bioactivities. In our on-going
program of screening these kinds of constituents from natural products, Yucca schidigera …

Abstract The comparative metabolism of (+)-and (−)-gossypol in rats was studied. After oral
administration of the drugs to rats, the half-lives of (+)-and (−)-gossypol in the …

Understanding how the natural products structural diversity interacts with cellular
metabolism and infectious disease targets remains a challenge. Inflammation is an …

Gossypol is a polyphenolic aldehyde occurring naturally in cottonseed that produces
antisteroidogenic activity in vivo, has been extensively investigated as a male contraceptive …

Diosgenin, a naturally occurring steroidal saponin, has been confirmed to possess potent
anticancer properties. In the current work, two series of novel diosgenin derivatives bearing …

Giosgenin is a naturally steroidal saponin exhibiting a variety of biological activities
including antitumor ones. A series of novel diosgenyl quaternary ammonium derivatives …

Metastasis is the most prevalent cause of treatment failure in patients with colon cancer.
Gossypol is reported to exhibit antioxidant, anticancer, antivirus and antimicrobial properties …

Natural gossypol (GP), a polyphenolic pigment in cottonseed, is a racemic mixture of two
enantiomers,(+) GP and (-) GP. Our aim was to compare the abilities of (+/-) GP,(+) GP and …

A concentrated mixture of gossypol, 6-methoxy-gossypol, and 6, 6′-dimethoxy-gossypol
was extracted from the root bark of St. Vincent Sea Island cotton with acetone. This extract …

Diosgenin, an important steroid sapogenin, is one of major precursors of synthetic steroids. It
is rich in natural resources and has various significant activities such as anti-tumor, anti …