Curcumin has been shown to possess strong anti-inflammatory activity in many diseases. It
has been demonstrated that the janus kinase 2 (JAK2)-signal transducer and activator of …

Background. Osteoarthritis (OA) is a progressive illness that destroys cartilage. Oxidative
stress is a major contributor of OA, while endoplasmic reticulum (ER) stress is the key …

Background The underlying mechanisms of neuropathic pain remain unclear. This work
aimed to investigate the role of Sirtuin3 (SIRT3), an nicotinamide adenosine dinucleotide+ …

Brain-derived neurotrophic factor (BDNF), in addition to its neurotrophic action, also
possesses antioxidant activities. However, the underlying mechanisms remain to be fully …

Shifting microglial polarization from M1 toward M2 phenotype represents a promising
therapeutic strategy for neuropathic pain (NP). Dual-specificity phosphatase-1 (DUSP1) is a …

Oxidative stress has been recognized as the contributor to diabetic peripheral neuropathy
(DPN). Antioxidant strategies have been most widely explored; nevertheless, whether …

Reactive oxygen species (ROS) scavengers have been shown to relieve persistent pain;
however, the mechanism is not clearly understood. Superoxide produced from mitochondrial …

Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by
dysfunctional inflammatory response. However, no effective therapeutic options have been …

Physiological reactive oxygen species (ROS) play an important role in cellular signal
transduction. However, excessive ROS is an important pathological mechanism in most …

Abnormal histone acetylation occurs during neuropathic pain through an epigenetic
mechanism. Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase …