Background The exposure of the nucleus pulposus (NP) causes an immune and
inflammatory response, which is intrinsically linked to the pathogenesis of radicular pain. As …

Neuropathic pain (NP) is a frustrating and burdensome problem. Current treatments for NP
have unendurable side effects and/or questionable efficacy, and once these therapies are …

Melatonin is reportedly associated with intervertebral disc degeneration (IDD). Endplate
cartilage is vitally important to intervertebral discs in physiological and pathological …

Knee osteoarthritis (KOA) is a disabling chronic inflammatory disease that is closely
associated with synovium tissue hypoxia and synovial fibrosis. Casticin, a compound …

Mitochondrial dysfunction plays a major role in the development of intervertebral disc
degeneration (IDD). Sirtuin 5 (SIRT5) participates in the maintenance of mitochondrial …

Abstract The mitochondrial sirtuin 3 (SIRT3) is involved in suppressing the onset of multiple
pathologies, including cardiovascular disease, fatty liver, age-related hearing loss, and …

Background Recent data have suggested a relationship between acute arthritic pain and
acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The …

Abstract Introduction Semaphorin 4A (Sema4A) plays critical roles in many physiological
and pathological processes including neuronal development, angiogenesis, immune …

Abstract Sphingosine-1-phosphate (S1P) receptor 1 subtype (S1PR1) activation by its ligand
S1P in the dorsal horn of the spinal cord causes mechanohypersensitivity. The cellular and …

Previous studies have demonstrated that microRNAs (miRNAs) play important roles in the
pathogenesis of neuropathic pain. In the present study, we found that miR-32-5p was …