Maresin 1 attenuates radicular pain through the inhibition of NLRP3 inflammasome-induced pyroptosis via NF-κB signaling
Y Wang, Y Li, J Wang, Q Zhao, J Jin, S Wen… - Frontiers in …, 2020 - frontiersin.org
Background The exposure of the nucleus pulposus (NP) causes an immune and
inflammatory response, which is intrinsically linked to the pathogenesis of radicular pain. As …
inflammatory response, which is intrinsically linked to the pathogenesis of radicular pain. As …
Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain
A Ge, S Wang, B Miao, M Yan - Molecular Medicine …, 2018 - spandidos-publications.com
Neuropathic pain (NP) is a frustrating and burdensome problem. Current treatments for NP
have unendurable side effects and/or questionable efficacy, and once these therapies are …
have unendurable side effects and/or questionable efficacy, and once these therapies are …
Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1‐autophagy pathway
Z Zhang, J Lin, N Tian, Y Wu, Y Zhou… - Journal of Cellular …, 2019 - Wiley Online Library
Melatonin is reportedly associated with intervertebral disc degeneration (IDD). Endplate
cartilage is vitally important to intervertebral discs in physiological and pathological …
cartilage is vitally important to intervertebral discs in physiological and pathological …
Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1α/NLRP3 inflammasome signaling
X Li, W Mei, Z Huang, L Zhang, B Xu, X Shi… - International …, 2020 - Elsevier
Knee osteoarthritis (KOA) is a disabling chronic inflammatory disease that is closely
associated with synovium tissue hypoxia and synovial fibrosis. Casticin, a compound …
associated with synovium tissue hypoxia and synovial fibrosis. Casticin, a compound …
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis
Mitochondrial dysfunction plays a major role in the development of intervertebral disc
degeneration (IDD). Sirtuin 5 (SIRT5) participates in the maintenance of mitochondrial …
degeneration (IDD). Sirtuin 5 (SIRT5) participates in the maintenance of mitochondrial …
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice
JE Huh, JH Shin, ES Jang, SJ Park, DR Park, R Ko… - Scientific reports, 2016 - nature.com
Abstract The mitochondrial sirtuin 3 (SIRT3) is involved in suppressing the onset of multiple
pathologies, including cardiovascular disease, fatty liver, age-related hearing loss, and …
pathologies, including cardiovascular disease, fatty liver, age-related hearing loss, and …
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis
M Izumi, M Ikeuchi, Q Ji, T Tani - Journal of biomedical science, 2012 - Springer
Background Recent data have suggested a relationship between acute arthritic pain and
acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The …
acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The …
Expression of Semaphorin 4A and its potential role in rheumatoid arthritis
L Wang, G Song, Y Zheng, W Tan, J Pan… - Arthritis research & …, 2015 - Springer
Abstract Introduction Semaphorin 4A (Sema4A) plays critical roles in many physiological
and pathological processes including neuronal development, angiogenesis, immune …
and pathological processes including neuronal development, angiogenesis, immune …
[HTML][HTML] Activation of sphingosine-1-phosphate receptor 1 in the spinal cord produces mechanohypersensitivity through the activation of inflammasome and IL-1β …
TM Doyle, Z Chen, M Durante, D Salvemini - The journal of pain, 2019 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) receptor 1 subtype (S1PR1) activation by its ligand
S1P in the dorsal horn of the spinal cord causes mechanohypersensitivity. The cellular and …
S1P in the dorsal horn of the spinal cord causes mechanohypersensitivity. The cellular and …
miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain
T Yan, F Zhang, C Sun, J Sun, Y Wang, X Xu… - Biochemical and …, 2018 - Elsevier
Previous studies have demonstrated that microRNAs (miRNAs) play important roles in the
pathogenesis of neuropathic pain. In the present study, we found that miR-32-5p was …
pathogenesis of neuropathic pain. In the present study, we found that miR-32-5p was …