Novel O-glycosidic gossypol isomers and their bioactivities
J Yin, L Jin, F Chen, X Wang, A Kitaygorodskiy… - Carbohydrate …, 2011 - Elsevier
Novel glycosidic gossypol analogs, 7, 7′-gossypol diglucoside tetraacetate GS1, 6, 7′-
gossypol diglucoside tetraacetate GS2, 7, 7′-gossypol diglycoside GS1′, 6, 7′-gossypol …
gossypol diglucoside tetraacetate GS2, 7, 7′-gossypol diglycoside GS1′, 6, 7′-gossypol …
Chemical modification and biological activity exploration of the natural product-gossypol
J Yin - 2010 - tigerprints.clemson.edu
Gossypol is a naturally occurring, highly colored yellow pigment indigenous to the small
intercellular pigment glands of the cotton plant genus Gossypium, which is proposed to be …
intercellular pigment glands of the cotton plant genus Gossypium, which is proposed to be …
Preparation and functional analysis of gossypols having two carbohydrate appendages with enaminooxy linkages
Y Amano, M Nakamura, S Shiraishi, N Chigira… - Carbohydrate …, 2018 - Elsevier
We developed new gossypol (Gos)-based glycoconjugates through dehydration
condensation of native Gos and chemically modified glycosides having aminooxy groups …
condensation of native Gos and chemically modified glycosides having aminooxy groups …
Recent advances in gossypol derivatives and analogs: a chemistry and biology view
Y Lu, J Li, CE Dong, J Huang, HB Zhou… - Future Medicinal …, 2017 - Taylor & Francis
Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic
contexts for a long time. The chemical modifications on gossypol were limited due to the …
contexts for a long time. The chemical modifications on gossypol were limited due to the …
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design
Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
Structure-activity studies on gossypol in tumor cell lines
MD Shelley, L Hartley, PW Groundwater… - Anti-cancer …, 2000 - journals.lww.com
Abstract Gossypol [(2, 2′-binaphthalene)-8, 8′-dicarboxaldehyde-1, 1′, 6, 6′, 7, 7′-
hexahydroxy-5, 5′-diisopropyl-3, 3′-dimethyl] 1a is a naturally occurring compound …
hexahydroxy-5, 5′-diisopropyl-3, 3′-dimethyl] 1a is a naturally occurring compound …
Efficient synthesis of α-and β-chacotriosyl glycosides using appropriate donors, and their cytotoxic activity
H Miyashita, Y Kai, T Nohara, T Ikeda - Carbohydrate research, 2008 - Elsevier
Natural steroidal glycosides containing α-l-rhamnopyranosyl-(1→ 4)-[α-l-rhamnopyranosyl-
(1→ 2)]-β-d-glucopyranose (chacotriose) at the oligosaccharide moiety exhibit anti-cancer …
(1→ 2)]-β-d-glucopyranose (chacotriose) at the oligosaccharide moiety exhibit anti-cancer …
Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases
Despite the vast amounts of research and remarkable discoveries that have been made in
recent decades, cancer remains a leading cause of death and a major public health concern …
recent decades, cancer remains a leading cause of death and a major public health concern …
Natural product gossypol and its derivatives in precision cancer medicine
Gossypol, a natural product extracted from the seed, roots, and stem of cotton, was initially
used as a male contraceptive but was subsequently investigated as a novel antitumor agent …
used as a male contraceptive but was subsequently investigated as a novel antitumor agent …
Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling
L Zhang, H Jiang, X Cao, H Zhao, F Wang, Y Cui… - European Journal of …, 2009 - Elsevier
To better use gossypol to find promising anticancer compounds, a series of new and known
bis-Schiff base analogs of chiral gossypol were synthesized, and their anticancer activity on …
bis-Schiff base analogs of chiral gossypol were synthesized, and their anticancer activity on …