Compound 1 ((−)-gossypol) has been long known as a chemical anticancer agent. With its
low water solubility and toxicity, it is not widely used as a commercial drug. To overcome …

Gossypol, a complex polyphenolic compound, is a naturally occurring highly colored yellow
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …

For further structure–activity relationship (SAR) research of OSW saponins, a cholestane
glycoside, namely 3β, 16β, 26-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl …

The development of simple and rapid analytical tools for gossypol (GSP) is important to the
food industry and medical field. Here, we report a matrix-assisted laser desorption/ionization …

Preclinical and clinical studies have pointed to the antitumor potential of the naturally
occurring polyphenolic binaphthyl dialdehyde, gossypol, as well as its purified (−,+) …

1, l'-Dideoxygossypol (DDG), 1, l'-dideoxygossylic acid (DDGA), 8-deoxyhemigossypol
(DHG), and 8-deoxyhemigossylic acid (DHGA) were synthesized and tested fortheir ability to …

The natural polyphenol gossypol possesses many therapeutic benefits. Here we aim to
determine the elimination pathways of gossypol in vivo and in vitro. 2. Metabolite elucidation …

To discover new potent cytotoxic steroidal saponins, a series of tigogenin neoglycosides
were synthesized via oxyamine neoglycosylation for the first time. The preliminary bioassays …

Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone
groups were synthesized concisely. The cytotoxicities of the synthetic compounds on six …

The chemistry of gossypol is very relevant to its unique actions. The two aldehyde groups
can easily bind to proteins via aldehyde-amino group linkage. Gossypolone, the in vivo …