Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis
Ergosterol 3-O-β-d-glucopyranoside (1a) and ergosterol 3-O-β-d-galactopyranoside (1b)
were highly efficiently synthesized and evaluated for their inhibitory activities against two …
were highly efficiently synthesized and evaluated for their inhibitory activities against two …
Synthesis and cytotoxicities of icogenin analogues with disaccharide residues
H Wang, F Su, L Zhou, X Chen, P Lei - Bioorganic & medicinal chemistry …, 2009 - Elsevier
For further structure–activity relationships (SAR) research of furostan saponin, two icogenin
analogues:(25R)-22-O-methyl-furost-5-en-3β, 26-diol-3-O-α-l-rhamnopyranosyl-(1→ 2)-β-d …
analogues:(25R)-22-O-methyl-furost-5-en-3β, 26-diol-3-O-α-l-rhamnopyranosyl-(1→ 2)-β-d …
Efficient synthesis of glycyrrhetinic acid glycoside/glucuronide derivatives using silver zeolite as promoter
MC del Ruiz Ruiz, H Amer, C Stanetty, I Beseda… - Carbohydrate …, 2009 - Elsevier
3-O-Glycopyranosides of glycyrrhetinic acid have been synthesized in good to high yields
and excellent stereoselectivity using glycosyl bromide donors and silver zeolite as promoter …
and excellent stereoselectivity using glycosyl bromide donors and silver zeolite as promoter …
Synthesis of cholestane saponins as mimics of OSW-1 and their cytotoxic activities
D Zheng, Y Guan, X Chen, Y Xu, X Chen… - Bioorganic & medicinal …, 2011 - Elsevier
To fulfill the structure–activity relationship (SAR) of OSW-1, and aim at finding the simplest
structural part while maintaining most of the biological activities, six cholestane saponins …
structural part while maintaining most of the biological activities, six cholestane saponins …
[HTML][HTML] Gastric floating tablet improves the bioavailability and reduces the hypokalemia effect of gossypol in vivo
H Liu, S Wang, H Shi, R Zhang, K Qu, Y Hu… - Saudi Pharmaceutical …, 2021 - Elsevier
Gossypol (Gos) is a natural polyphenolic compound that has shown a number of valuable
biological properties such as antifertility, antioxidation, and antitumor activities. However, the …
biological properties such as antifertility, antioxidation, and antitumor activities. However, the …
Preparation of enantiomeric gossypol by crystallization
MK Dowd - Chirality, 2003 - Wiley Online Library
Large enantiomorphic crystals of gossypol‐acetone (1: 3) were grown from acetone
solutions of rac‐gossypol‐acetic acid (1: 1) at 4° C. By controlling the initial gossypol …
solutions of rac‐gossypol‐acetic acid (1: 1) at 4° C. By controlling the initial gossypol …
Concise synthesis and antitumor activities of trisaccharide steroidal saponins
G Gu, M Fang, J Liu, L Gu - Carbohydrate research, 2011 - Elsevier
The naturally derived trisaccharide steroidal saponin 1 and structurally modified derivatives
2 and 3 bearing the same sarsasapogenin aglycon were synthesized concisely via a direct …
2 and 3 bearing the same sarsasapogenin aglycon were synthesized concisely via a direct …
Investigations on gossypol: past and present developments
K Dodou - Expert opinion on investigational drugs, 2005 - Taylor & Francis
Gossypol has received significant attention as a result of its potential therapeutic application
as a male antifertility agent. Furthermore, recent research examining the biological activity of …
as a male antifertility agent. Furthermore, recent research examining the biological activity of …
Synthesis of solasodine glycoside derivatives and evaluation of their cytotoxic effects on human cancer cells
C Cui, X Wen, M Cui, J Gao, B Sun… - Drug discoveries & …, 2012 - jstage.jst.go.jp
Solasodine glycosides, such as solamargine, have been proved to be very important anti-
cancer agents. In order to discover more potent cytotoxic agents and explore the preliminary …
cancer agents. In order to discover more potent cytotoxic agents and explore the preliminary …
An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines
ML Leblanc, J Russo, AP Kudelka, JA Smith - Pharmacological research, 2002 - Elsevier
Gossypol, a cottonseed extract, has been shown to have antiproliferative activity in a variety
of cancer cell lines. The objective of this study was to determine the inhibitory effects of …
of cancer cell lines. The objective of this study was to determine the inhibitory effects of …