Cardiac SERCA2A/B: therapeutic targets for heart failure
MA Shareef, LA Anwer, C Poizat - European journal of pharmacology, 2014 - Elsevier
Abstract Calcium (Ca 2+) recycling is key for effective relaxation of the cardiac muscle.
Failure to properly recycle calcium through the sarcoplasmic reticulum (SR) results in severe …
Failure to properly recycle calcium through the sarcoplasmic reticulum (SR) results in severe …
[HTML][HTML] Attenuation of the upregulation of NF‑κB and AP‑1 DNA‑binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by …
Z Qu, X Lu, Y Qu, T Tao, X Liu… - … journal of molecular …, 2021 - spandidos-publications.com
The present study aimed to investigate the effects of the overexpression of
sarco/endoplasmic reticulum Ca 2+‑ATPase (SERCA2a) on endoplasmic reticulum (ER) …
sarco/endoplasmic reticulum Ca 2+‑ATPase (SERCA2a) on endoplasmic reticulum (ER) …
NBR1-mediated autophagic degradation of caspase 8 protects vascular endothelial cells against arsenite-induced apoptotic cell death
S Hu, F Wang, L Mao, X Jiang, Y Luo, X Qin… - Biochemical and …, 2024 - Elsevier
Vascular endothelial cells play a critical role in maintaining the health of blood vessels, but
dysfunction can lead to cardiovascular diseases. The impact of arsenite exposure on …
dysfunction can lead to cardiovascular diseases. The impact of arsenite exposure on …
[HTML][HTML] Selective SERCA2a activator as a candidate for chronic heart failure therapy
M Arici, SC Hsu, M Ferrandi, P Barassi… - Journal of Translational …, 2024 - Springer
Background The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression
substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that …
substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that …
Sarco/endoplasmic reticulum Ca2+ ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress
C Chaâbane, E Corvazier, R Bredoux, S Dally… - Biochemical and …, 2006 - Elsevier
Sarco/endoplasmic reticulum Ca2+ ATPases (SERCAs) pump free Ca2+ from the cytosol
into the endoplasmic reticulum. The human SERCA3 family counts six members named …
into the endoplasmic reticulum. The human SERCA3 family counts six members named …
[HTML][HTML] Clearance of stress-induced premature senescent cells alleviates the formation of abdominal aortic aneurysms
J Xie, Z Tang, Q Chen, X Jia, C Li, M Jin, G Wei… - Aging and …, 2023 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by various
pathophysiological processes, including chronic inflammation, oxidative stress, and …
pathophysiological processes, including chronic inflammation, oxidative stress, and …
[HTML][HTML] Overexpression of SERCA2b in the heart leads to an increase in sarcoplasmic reticulum calcium transport function and increased cardiac contractility
AL Greene, MJ Lalli, Y Ji, GJ Babu, I Grupp… - Journal of Biological …, 2000 - ASBMB
The sarcoplasmic reticulum calcium ATPase SERCA2b is an alternate isoform encoded by
the SERCA2 gene. SERCA2b is expressed ubiquitously and has a higher Ca 2+ affinity …
the SERCA2 gene. SERCA2b is expressed ubiquitously and has a higher Ca 2+ affinity …
Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum
M Shimura, S Minamisawa, H Takeshima… - Cardiovascular …, 2008 - academic.oup.com
Aims Sarcalumenin (SAR) is a Ca2+-binding protein expressed in the longitudinal
sarcoplasmic reticulum (SR) of striated muscle cells. Although its Ca2+-binding property is …
sarcoplasmic reticulum (SR) of striated muscle cells. Although its Ca2+-binding property is …
[HTML][HTML] Calcium homeostasis and endoplasmic reticulum stress are involved in Salvianolic acid B-offered protection against cardiac toxicity of arsenic trioxide
JY Zhang, B Zhang, M Wang, W Wang, P Liao… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Arsenic trioxide (ATO) is a potent anticancer agent used to treat acute promyelocytic
leukemia. However, its cardiotoxicity limits ATO's widespread clinical use. Previous studies …
leukemia. However, its cardiotoxicity limits ATO's widespread clinical use. Previous studies …