Total synthesis of zaragozic acid A (squalestatin S1). Degradation to a relay compound and reassembly of the natural product

D Stoermer, S Caron… - The Journal of Organic …, 1996 - ACS Publications
Zaragozic acid A (squalestatin S1)(1) was converted into the simpler derivative 2, which was
reconverted into the natural product, thus establishing 2 as a viable relay compound for total …

Araguspongines K and L, New Bioactive Bis-1-oxaquinolizidine N-Oxide Alkaloids from Red Sea Specimens of Xestospongia exigua

KY Orabi, KA El Sayed, MT Hamann… - Journal of natural …, 2002 - ACS Publications
In addition to the previously reported (+)-araguspongine A,(+)-araguspongine C,(+)-
araguspongine D,(−)-araguspongine E, and (+)-xestospongin B, two new N-oxide …

Structures of xestospongin A, B, C and D, novel vasodilativecompounds from marine sponge, Xestospongia exigua

M Nakagawa, M Endo, N Tanaka, L Gen-Pei - Tetrahedron Letters, 1984 - Elsevier
Tetrahedron Letters,Vo1.25,No.30,pp 3227-3230,1984 0040-4039/84 $3.00 + .oO Printed in
Great Britain 01984 Pergamon Press Ltd. S Page 1 Tetrahedron Letters,Vo1.25,No.30,pp …

(+)-7S-Hydroxyxestospongin A from the Marine Sponge Xestospongia sp. and Absolute Configuration of (+)-Xestospongin D

SS Moon, JB MacMillan, MM Olmstead… - Journal of natural …, 2002 - ACS Publications
The structure of the title compound,(+)-7 S-hydroxyxestospongin A was solved by single-
crystal X-ray diffraction analysis and the absolute stereochemistry obtained by analysis of …

Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone

V Popsavin, B Srećo, G Benedeković, J Francuz… - European journal of …, 2010 - Elsevier
This paper describes a straightforward divergent synthesis of (+)-goniofufurone mimics (4, 5
and 6) starting from d-xylose. In a preliminary bioassay, analogues 4 and 5 exhibited a …

Design, synthesis, and antifungal activities of hymexazol glycosides based on a biomimetic strategy

K Gao, Y Qin, L Wang, X Li, S Liu, R Xing… - Journal of Agricultural …, 2022 - ACS Publications
Hymexazol (HYM) is irreplaceable for treating soil-borne diseases due to its high efficiency
and low cost, as a broad-spectrum fungicide. However, when HYM is absorbed by plants, it …

[HTML][HTML] Madecassic Acid—A new scaffold for highly cytotoxic agents

O Kraft, AK Hartmann, S Hoenke, I Serbian… - International Journal of …, 2022 - mdpi.com
Due to their manifold biological activities, natural products such as triterpenoids have
advanced to represent excellent leading structures for the development of new drugs. For …

New derivatives of saikosaponins

K Shimizu, S Amagaya, Y Ogihara - Chemical and Pharmaceutical …, 1985 - jstage.jst.go.jp
抄録 In the course of studies on the metabolism of saikosaponins, which are the main
constituents of Bupleurum falcatum L., five new compounds derived from saikosaponins a, c …

Enantioselective synthesis of altohyrtin C (spongistatin 2): synthesis of the AB‐and CD‐spiroketal subunits

DA Evans, PJ Coleman, LC Dias - … Chemie International Edition …, 1997 - Wiley Online Library
The spongipyran macrolides, a new class of marine natural products, exhibit subnanomolar
antitumor activities against a number of human cancer cell lines. Independent …

Total synthesis of (+)-spongistatin 1. An effective second-generation construction of an advanced EF Wittig salt, fragment union, and final elaboration

AB Smith, W Zhu, S Shirakami, C Sfouggatakis… - Organic …, 2003 - ACS Publications
A stereocontrolled, total synthesis of (+)-spongistatin 1 (1) has been achieved. Union of a
second-generation EF Wittig salt (+)-3 with the advanced ABCD aldehyde (−)-4, followed by …