Natural gossypol (GP), a polyphenolic pigment in cottonseed, is a racemic mixture of two
enantiomers,(+) GP and (-) GP. Our aim was to compare the abilities of (+/-) GP,(+) GP and …

Gossypol (GP), a male contraceptive compound naturally present in cottonseed products,
possesses anti-proliferative and anti-metastatic effects in vitro and in vivo. However, the …

Natural compounds capable of inducing apoptosis in cancer cells have always been of
considerable interest as potential anti-cancer agents. Many such compounds are under …

A novel chemical process has been devised for the synthesis of a new derivative of
gossypol, 6, 7, 6′, 7′‐tetrahydroxy‐5, 5′‐diisopropyl‐3, 3′‐dimethyl‐[2, 2'] …

Abstract Purpose 5-Fluorouracil (5-FU) is the basic chemotherapeutic agent used to treat
colon cancer. However, the sensitivity of colon cancer cells to 5-FU is limited. Gossypol is a …

Dysregulation of Bcl2 family member proteins has been associated with poor
chemotherapeutic response in bladder cancer, suggesting that agents targeting these …

Lung cancer is the most prevalent in cancer-related deaths, while breast carcinoma is the
second most dominant cancer in women, accounting for the most number of deaths …

Gossypin is a flavone that was originally isolated from Hibiscus vitifolius and has traditionally
been used for the treatment of diabetes, jaundice, and inflammation. Recently, gossypin was …

The chemistry of gossypol is very relevant to its unique actions. The two aldehyde groups
can easily bind to proteins via aldehyde-amino group linkage. Gossypolone, the in vivo …

A series of gypsogenin (1) derivatives (1a–i) was synthesized in good yields, and the
derivatives' structures were established using UV, IR, 1 H NMR, 13 C NMR, and LCMS …