Cytotoxic effect of gossypol on colon carcinoma cells
X Wang, J Wang, SCH Wong, LSN Chow, JM Nicholls… - Life Sciences, 2000 - Elsevier
Gossypol, a male contraceptive drug extracted from cottonseeds, has been found to have
antiproliferative activity on tumour cells and is thought to be a potential anticancer drug. The …
antiproliferative activity on tumour cells and is thought to be a potential anticancer drug. The …
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells
M Zhang, H Liu, R Guo, Y Ling, X Wu, B Li… - Biochemical …, 2003 - Elsevier
Gossypol, a male contraceptive drug, has been demonstrated to have antiproliferative and
antimetastatic effects on many kinds of cancer cells in vitro. HT-29 human carcinoma cell …
antimetastatic effects on many kinds of cancer cells in vitro. HT-29 human carcinoma cell …
Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells
L Huang, J Hu, W Tao, Y Li, G Li, P Xie, X Liu… - European journal of …, 2010 - Elsevier
Gossypol is an attractive therapeutic anti-tumor agent as an apoptosis inducer and is being
evaluated in preclinical tests. However, the molecular mechanisms underlying apoptosis …
evaluated in preclinical tests. However, the molecular mechanisms underlying apoptosis …
Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells
Plant polyphenol gossypol has anticancer activities. This may increase cottonseed value by
using gossypol as a health intervention agent. It is necessary to understand its molecular …
using gossypol as a health intervention agent. It is necessary to understand its molecular …
Upregulation of Fas/Fas ligand‐mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line
JS Chang, YL Hsu, PL Kuo… - Clinical and …, 2004 - Wiley Online Library
Gossypol has wide antineoplastic effects in vitro, but its effects on human lung cancer have
not been explored. 2. To evaluate the activity of gossypol against alveolar cell lung cancer …
not been explored. 2. To evaluate the activity of gossypol against alveolar cell lung cancer …
The potential roles of gossypol as anticancer agent: advances and future directions
D Paunovic, J Rajkovic, R Novakovic… - Chinese Medicine, 2023 - Springer
Gossypol, a polyphenolic aldehyde derived from cottonseed plants, has seen a
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
The role of COX‐2/PGE2 in gossypol‐induced apoptosis of colorectal carcinoma cells
CC Chien, CH Ko, SC Shen, LY Yang… - Journal of cellular …, 2012 - Wiley Online Library
Our previous study showed that gossypol (GOS) exhibits potent cytotoxic effects via
apoptosis induction against human colorectal carcinoma cells; however, the role of …
apoptosis induction against human colorectal carcinoma cells; however, the role of …
Gossypol Induces Apoptosis by Activating p53 in Prostate Cancer Cells and Prostate Tumor–Initiating Cells
SR Volate, BT Kawasaki, EM Hurt, JA Milner… - Molecular cancer …, 2010 - AACR
Prostate cancer continues to represent a burgeoning medical problem in the United States.
Recent studies suggest that gossypol, a bioactive phytochemical produced by cotton plants …
Recent studies suggest that gossypol, a bioactive phytochemical produced by cotton plants …
Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent-and independent-signaling
J Jiang, V Slivova, A Jedinak, D Sliva - Clinical & experimental metastasis, 2012 - Springer
Although previous studies demonstrated anticancer activities of gossypol through the
induction of apoptosis, the molecular mechanism (s) responsible for the inhibitory effects of …
induction of apoptosis, the molecular mechanism (s) responsible for the inhibitory effects of …
Gossypol suppresses NF-κB activity and NF-κB-related gene expression in human leukemia U937 cells
DO Moon, MO Kim, JD Lee, GY Kim - Cancer letters, 2008 - Elsevier
Recent studies indicate that gossypol possesses potent antitumor activities in vitro and in
vivo. The nuclear factor-kappa B (NF-κB) plays an important role in tumor cell growth …
vivo. The nuclear factor-kappa B (NF-κB) plays an important role in tumor cell growth …