Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …
us uniquely human. The development of the brain is a highly complex process, and this …
Between destiny and disease: genetics and molecular pathways of human central nervous system aging
C Glorioso, E Sibille - Progress in neurobiology, 2011 - Elsevier
Aging of the human brain is associated with “normal” functional, structural, and molecular
changes that underlie alterations in cognition, memory, mood and motor function, amongst …
changes that underlie alterations in cognition, memory, mood and motor function, amongst …
[HTML][HTML] An epigenetic predictor of death captures multi-modal measures of brain health
Individuals of the same chronological age exhibit disparate rates of biological ageing.
Consequently, a number of methodologies have been proposed to determine biological age …
Consequently, a number of methodologies have been proposed to determine biological age …
A genome-wide scan for common variants affecting the rate of age-related cognitive decline
Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic
conditions of aging, including neurodegenerative and vascular disease. Because common …
conditions of aging, including neurodegenerative and vascular disease. Because common …
[HTML][HTML] Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases
Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …
have identified loci that harbor risk variants for neurodegenerative diseases, including …
The evolution of the human brain and disease susceptibility
Evolutionary perspective is critical for understanding human biology, human medicine, and
the traits that make human beings unique. One of the crucial characteristics that sets …
the traits that make human beings unique. One of the crucial characteristics that sets …
Assessment of neurobiological mechanisms of cortical thinning during childhood and adolescence and their implications for psychiatric disorders
Importance Many psychiatric disorders can be conceptualized as disorders of brain
maturation during childhood and adolescence. Discovering the neurobiological …
maturation during childhood and adolescence. Discovering the neurobiological …
Developmental regulation of human cortex transcription and its clinical relevance at single base resolution
Transcriptome analysis of human brain provides fundamental insight into development and
disease, but it largely relies on existing annotation. We sequenced transcriptomes of 72 …
disease, but it largely relies on existing annotation. We sequenced transcriptomes of 72 …
Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group
RM Brouwer, MS Panizzon, DC Glahn… - Human brain …, 2017 - Wiley Online Library
Structural brain changes that occur during development and ageing are related to mental
health and general cognitive functioning. Individuals differ in the extent to which their brain …
health and general cognitive functioning. Individuals differ in the extent to which their brain …