Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer

P Kovacic - Current medicinal chemistry, 2003 - ingentaconnect.com
Gossypol, a constituent of cottonseeds, displays various drug properties, including
antifertility and anticancer. Toxicity is shown against the reproductive system, heart, liver …

Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design

Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …

Bioactivities of gossypol, 6-methoxygossypol, and 6, 6′-dimethoxygossypol

X Wang, TH Beckham, JC Morris, F Chen… - Journal of agricultural …, 2008 - ACS Publications
6-Methoxygossypol and 6, 6′-dimethoxygossypol were recently isolated from the root
tissue of cotton plants. Together with gossypol, these natural products were investigated for …

Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)-and (−)-stereoisomers

Y Yu-Wen - Journal of ethnopharmacology, 1987 - Elsevier
The chemistry of gossypol is very relevant to its unique actions. The two aldehyde groups
can easily bind to proteins via aldehyde-amino group linkage. Gossypolone, the in vivo …

Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm

A de Peyster, A Quintanilha, L Packer… - … and biophysical research …, 1984 - Elsevier
Gossypol, a polyphenolic compound found in cotton plants, has many potential uses,
including use as a male antifertility drug and spermicide. Gossypol affects a variety of cell …

Gossypol-a polyphenolic compound from cotton plant

X Wang, CP Howell, F Chen, J Yin, Y Jiang - Advances in food and nutrition …, 2009 - Elsevier
Abstract Gossypol (C 30 H 30 O 8) is a polyphenolic compound derived from the cotton plant
(genus Gossypium, family Malvaceae). The presence of six phenolic hydroxyl groups and …

Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases

D Pal, P Sahu, G Sethi, CE Wallace, A Bishayee - Pharmaceutics, 2022 - mdpi.com
Despite the vast amounts of research and remarkable discoveries that have been made in
recent decades, cancer remains a leading cause of death and a major public health concern …

Reaction chemistry of gossypol and its derivatives

JA Kenar - Journal of the American Oil Chemists' Society, 2006 - Wiley Online Library
Gossypol, a complex polyphenolic compound, is a naturally occurring highly colored yellow
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …

Investigations on gossypol: past and present developments

K Dodou - Expert opinion on investigational drugs, 2005 - Taylor & Francis
Gossypol has received significant attention as a result of its potential therapeutic application
as a male antifertility agent. Furthermore, recent research examining the biological activity of …

Gossypol prototype of inhibitors targeted to dinucleotide folds

DL Vander Jagt, RE Royer - Current medicinal chemistry, 2000 - ingentaconnect.com
Gossypol, a disesquiterpene from cottonseed, exhibits multiple biological properties,
including male antifertility activity and anticancer activity. Gossypol also inhibits the growth of …