Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer
P Kovacic - Current medicinal chemistry, 2003 - ingentaconnect.com
Gossypol, a constituent of cottonseeds, displays various drug properties, including
antifertility and anticancer. Toxicity is shown against the reproductive system, heart, liver …
antifertility and anticancer. Toxicity is shown against the reproductive system, heart, liver …
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design
Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
Bioactivities of gossypol, 6-methoxygossypol, and 6, 6′-dimethoxygossypol
6-Methoxygossypol and 6, 6′-dimethoxygossypol were recently isolated from the root
tissue of cotton plants. Together with gossypol, these natural products were investigated for …
tissue of cotton plants. Together with gossypol, these natural products were investigated for …
Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)-and (−)-stereoisomers
Y Yu-Wen - Journal of ethnopharmacology, 1987 - Elsevier
The chemistry of gossypol is very relevant to its unique actions. The two aldehyde groups
can easily bind to proteins via aldehyde-amino group linkage. Gossypolone, the in vivo …
can easily bind to proteins via aldehyde-amino group linkage. Gossypolone, the in vivo …
Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm
A de Peyster, A Quintanilha, L Packer… - … and biophysical research …, 1984 - Elsevier
Gossypol, a polyphenolic compound found in cotton plants, has many potential uses,
including use as a male antifertility drug and spermicide. Gossypol affects a variety of cell …
including use as a male antifertility drug and spermicide. Gossypol affects a variety of cell …
Gossypol-a polyphenolic compound from cotton plant
X Wang, CP Howell, F Chen, J Yin, Y Jiang - Advances in food and nutrition …, 2009 - Elsevier
Abstract Gossypol (C 30 H 30 O 8) is a polyphenolic compound derived from the cotton plant
(genus Gossypium, family Malvaceae). The presence of six phenolic hydroxyl groups and …
(genus Gossypium, family Malvaceae). The presence of six phenolic hydroxyl groups and …
Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases
Despite the vast amounts of research and remarkable discoveries that have been made in
recent decades, cancer remains a leading cause of death and a major public health concern …
recent decades, cancer remains a leading cause of death and a major public health concern …
Reaction chemistry of gossypol and its derivatives
JA Kenar - Journal of the American Oil Chemists' Society, 2006 - Wiley Online Library
Gossypol, a complex polyphenolic compound, is a naturally occurring highly colored yellow
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …
Investigations on gossypol: past and present developments
K Dodou - Expert opinion on investigational drugs, 2005 - Taylor & Francis
Gossypol has received significant attention as a result of its potential therapeutic application
as a male antifertility agent. Furthermore, recent research examining the biological activity of …
as a male antifertility agent. Furthermore, recent research examining the biological activity of …
Gossypol prototype of inhibitors targeted to dinucleotide folds
DL Vander Jagt, RE Royer - Current medicinal chemistry, 2000 - ingentaconnect.com
Gossypol, a disesquiterpene from cottonseed, exhibits multiple biological properties,
including male antifertility activity and anticancer activity. Gossypol also inhibits the growth of …
including male antifertility activity and anticancer activity. Gossypol also inhibits the growth of …