Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells
Plant polyphenol gossypol has anticancer activities. This may increase cottonseed value by
using gossypol as a health intervention agent. It is necessary to understand its molecular …
using gossypol as a health intervention agent. It is necessary to understand its molecular …
Cytotoxic effect of gossypol on colon carcinoma cells
X Wang, J Wang, SCH Wong, LSN Chow, JM Nicholls… - Life Sciences, 2000 - Elsevier
Gossypol, a male contraceptive drug extracted from cottonseeds, has been found to have
antiproliferative activity on tumour cells and is thought to be a potential anticancer drug. The …
antiproliferative activity on tumour cells and is thought to be a potential anticancer drug. The …
Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways
SF Huang, SC Chu, LS Hsu, YC Tu, PN Chen… - Food & function, 2019 - pubs.rsc.org
Metastasis is the most prevalent cause of treatment failure in patients with colon cancer.
Gossypol is reported to exhibit antioxidant, anticancer, antivirus and antimicrobial properties …
Gossypol is reported to exhibit antioxidant, anticancer, antivirus and antimicrobial properties …
Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent-and independent-signaling
J Jiang, V Slivova, A Jedinak, D Sliva - Clinical & experimental metastasis, 2012 - Springer
Although previous studies demonstrated anticancer activities of gossypol through the
induction of apoptosis, the molecular mechanism (s) responsible for the inhibitory effects of …
induction of apoptosis, the molecular mechanism (s) responsible for the inhibitory effects of …
Apoptosis-inducing activity and antiproliferative effect of gossypin on PC-3 prostate cancer cells
I Cinar - Anti-Cancer Agents in Medicinal Chemistry (Formerly …, 2021 - ingentaconnect.com
Aim: The rapid growth, morbidity and mortality of prostate cancer, and the lack of effective
treatment have attracted great interest of researchers to find novel cancer therapies aiming …
treatment have attracted great interest of researchers to find novel cancer therapies aiming …
Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases
Despite the vast amounts of research and remarkable discoveries that have been made in
recent decades, cancer remains a leading cause of death and a major public health concern …
recent decades, cancer remains a leading cause of death and a major public health concern …
A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer
F Yan, XX Cao, HX Jiang, XL Zhao… - Journal of medicinal …, 2010 - ACS Publications
Compound 1 ((−)-gossypol) has been long known as a chemical anticancer agent. With its
low water solubility and toxicity, it is not widely used as a commercial drug. To overcome …
low water solubility and toxicity, it is not widely used as a commercial drug. To overcome …
[HTML][HTML] Gossypol induces apoptosis of human pancreatic cancer cells via CHOP/endoplasmic reticulum stress signaling pathway
S Lee, E Hong, E Jo, ZH Kim, KJ Yim… - … of Microbiology and …, 2022 - ncbi.nlm.nih.gov
Gossypol, a natural phenolic aldehyde present in cotton plants, was originally used as a
means of contraception, but is currently being studied for its anti-proliferative and anti …
means of contraception, but is currently being studied for its anti-proliferative and anti …
Gossypol suppresses NF-κB activity and NF-κB-related gene expression in human leukemia U937 cells
DO Moon, MO Kim, JD Lee, GY Kim - Cancer letters, 2008 - Elsevier
Recent studies indicate that gossypol possesses potent antitumor activities in vitro and in
vivo. The nuclear factor-kappa B (NF-κB) plays an important role in tumor cell growth …
vivo. The nuclear factor-kappa B (NF-κB) plays an important role in tumor cell growth …
The potential roles of gossypol as anticancer agent: advances and future directions
D Paunovic, J Rajkovic, R Novakovic… - Chinese Medicine, 2023 - Springer
Gossypol, a polyphenolic aldehyde derived from cottonseed plants, has seen a
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
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