Two important recent advances in Leishmania immunology are:(i) the demonstration of a
dramatic dichotomy in T helper 1 versus T helper 2 subset expansion leading to protection …

Leishmania are digenetic protozoa which inhabit two highly specific hosts, the sandfly where
they grow as motile, flagellated promastigotes in the gut, and the mammalian macrophage …

Leishmaniasis is one of the world's important infectious diseases. It is prevalent in tropical
and subtropical regions of the world and endemic in 88 countries, with two million new …

Susceptibility as opposed to resistance of mouse strains (eg, BALB/c vs C57BL/6) to
Leishmania major has been attributed to a defective Th1 and a predominant Th2-response …

The ability of Leishmania parasites to infect and persist in the antigen-presenting cell
population of their mammalian hosts is dependent on their ability to gain entry to their host …

The severity of disease caused by infection with Leishmania major depends critically on the
genetics of the host. Early induction of T helper (Th) 1-type immune responses in the …

Human leishmaniasis is a spectral disease that includes asymptomatic self-resolving
infection, localized skin lesions, and progressive visceral leishmaniasis. With some overlap …

In Leishmaniasis, as in many infectious diseases, clinical manifestations are determined by
the interaction between the genetics of the host and of the parasite. Here we describe …

Ninety per cent of the 500 000 annual new cases of visceral leishmaniasis (VL) occur in
India/Bangladesh/Nepal, Sudan and Brazil. Importantly, 80–90% of human infections are …

Identifying genetic risk factors for parasitic infections such as the leishmaniases could
provide important leads for improved therapies and vaccines. Until recently most genetic …