Background Cigarette smoking contributes to lung remodelling in chronic obstructive
pulmonary disease (COPD). As part of remodelling, peribronchiolar fibrosis is observed in …

Unfortunately, the research effort directed into chronic obstructive pulmonary disease
(COPD) has been disproportionately weak compared to its social importance, and indeed it …

Background The reticular basement membrane (Rbm) in smokers and especially smokers
with COPD is fragmented with" clefts" containing cells staining for the collagenase matrix …

Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

In chronic obstructive pulmonary disease (COPD), epithelial changes and subepithelial
fibrosis are salient features in conducting airways. Epithelial-to-mesenchymal transition …

Background Small airway fibrosis is the main contributor in airflow obstruction in chronic
obstructive pulmonary disease. Epithelial mesenchymal transition (EMT) has been …

Chronic obstructive pulmonary disease (COPD) is a complex condition, frequently with a mix
of airway and lung parenchymal damage. However, the earliest changes are in the small …

Background and objective: In COPD, the airways are chronically inflamed, and we have now
observed fragmentation of the reticular basement membrane (Rbm). This appears to be a …

The authors have reviewed the current literature on airway inflammation and remodeling in
smoking-related chronic obstructive pulmonary disease (COPD). Detailed data on airway …

Background Epithelial–mesenchymal transition (EMT) is the major pathophysiological
process in lung fibrosis observed in chronic obstructive pulmonary disease (COPD) and …