Emerging roles of ferroptosis in male reproductive diseases

W Yuan, Z Sun, G Ji, H Hu - Cell Death Discovery, 2023 - nature.com
Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid
peroxidation that leads to excessive lipid peroxidation in different cells. Ferroptosis is distinct …

Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome

O Beharier, K Kajiwara, Y Sadovsky - Placenta, 2021 - Elsevier
Programmed cell death is a central process in the control of tissue development, organismal
physiology, and disease. Ferroptosis is a recently identified form of programmed cell death …

Ferroptosis: a novel type of cell death in male reproduction

Y Su, Z Liu, K Xie, Y Ren, C Li, W Chen - Genes, 2022 - mdpi.com
Ferroptosis, an iron-dependent type of regulated cell death, is triggered by the accumulation
of lethal lipid peroxides. Due to its potential in exploring disease progression and highly …

Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis

Y Sun, M Sha, Y Qin, J Xiao, W Li, S Li… - Free Radical Biology and …, 2024 - Elsevier
Exposure to bisphenol A (BPA) during gestation leads to fetal growth restriction (FGR),
whereby the underlying mechanisms remain unknown. Here, we found that FGR patients …

Ferroportin expression and regulation in human placenta/fetal membranes: implications for ferroptosis and adverse pregnancy outcomes

SW Ng, C Lee, A Ng, SK Ng, F Arcuri, MD House… - Reproductive …, 2023 - Elsevier
Iron overload is associated with pregnancy complications. Ferroportin (FPN) is the only
known iron exporter in mammalian cells. We hypothesize that FPN is functionally important …

Spotlight on iron overload and ferroptosis: research progress in female infertility

J Zhang, T Su, Y Fan, C Cheng, L Xu - Life Sciences, 2023 - Elsevier
Iron is an essential trace element for organisms. However, iron overload, which is common
in haematological disorders (eg haemochromatosis, myelodysplastic syndromes, aplastic …

Ferroptosis is associated with oxygen-glucose deprivation/reoxygenation-induced Sertoli cell death

L Li, Y Hao, Y Zhao, H Wang… - International …, 2018 - spandidos-publications.com
Sertoli cell death contributes to spermatogenesis impairment, which is associated with male
infertility. Testicular ischemia‑reperfusion (I/R) injury induces the cell death of germ cells and …

[HTML][HTML] Materno-fetal iron transfer and the emerging role of ferroptosis pathways

J Zaugg, F Solenthaler, C Albrecht - Biochemical pharmacology, 2022 - Elsevier
A successful pregnancy and the birth of a healthy baby depend to a great extent on the
controlled supply of essential nutrients via the placenta. Iron is essential for mitochondrial …

Ferroptosis: The functions of Nrf2 in human embryonic stem cells

S Babaei-Abraki, F Karamali, MH Nasr-Esfahani - Cellular Signalling, 2023 - Elsevier
Human embryonic stem cells (hESCs) have the capacity of self-renewal as well as
differentiation towards three germ layer derivatives which makes them as a source of …

Inhibitory Effect of All-Trans Retinoic Acid on Ferroptosis in BeWo Cells Mediated by the Upregulation of Heme Oxygenase-1

T Matsuoka, K Kajiwara, T Kawasaki, S Wada… - Placenta, 2024 - Elsevier
Introduction This study aimed to explore the association between ferroptosis, a newly
identified type of cell death, and the role of retinoic acid in developing pregnancy …