The recently identified ferroptotic cell death is characterized by excessive accumulation of
hydroperoxy-arachidonoyl (C20: 4)-or adrenoyl (C22: 4)-phosphatidylethanolamine (Hp …

Human trophoblast cells play important role in embryo-fetal development. However,
trophoblast cells are sensitive to environmental carcinogens. Recently, we have discovered …

Bisphenol A is a common environmental factor and endocrine disruptor that exerts a
negative impact on male reproductive ability. By exploring bisphenol A-induced testicular …

Busulfan is commonly used for cancer chemotherapy, nevertheless it cause male infertility
via damaging the germ cells. Therefore, the underlying mechanism should be explored. In …

This study aims to explore the role of methyltransferase-like 3 (METTL3) modulation of
ferroptosis in the pathogenesis of trophoblast-mediated preeclampsia. The expression of …

Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-
19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of …

Ferroptosis, a cell death process driven by iron-dependent phospholipid peroxidation, has
been implicated in various diseases. There are two major surveillance mechanisms to …

Abstract Exposure to Di (2-ethylhexyl) phthalate (DEHP) has been associated with toxic
effects of the reproductive system. However, the exact mechanism remains to be elucidated …

Oxidative stress is a major cause of adverse outcomes in preeclampsia (PE). Ferroptosis, ie
programmed cell death from iron-dependent lipid peroxidation, likely mediates PE …

Ferroptosis is a new type of cell death different from apoptosis and necrosis, which can
regulate the accumulation of lipid peroxidation through different pathways, ultimately leading …