Ninety per cent of the 500 000 annual new cases of visceral leishmaniasis (VL) occur in
India/Bangladesh/Nepal, Sudan and Brazil. Importantly, 80–90% of human infections are …

Identifying genetic risk factors for parasitic infections such as the leishmaniases could
provide important leads for improved therapies and vaccines. Until recently most genetic …

A genome-wide scan was conducted for visceral leishmaniasis (VL) in Brazil. Initially, 405
markers were typed in 22 multicase pedigrees (28 nuclear families; 174 individuals; 66 …

Leishmaniasis is a disease of the subtropical and tropical spheres of the earth and has
various clinical manifestations. The different form of leishmaniasis includes cutaneous …

Familial aggregation, high relative risk to siblings, and segregation analysis, suggest genetic
control of visceral leishmaniasis in Brazil. Class II gene effects in mice, and high circulating …

With the human genome sequence in hand, emphasis is now focusing on genetic diversity
and its role in susceptibility to disease. In the Sudan, different tribes share the same …

Background The current disease model for leishmaniasis suggests that only a proportion of
infected individuals develop clinical disease, while others are asymptomatically infected due …

Two important recent advances in Leishmania immunology are:(i) the demonstration of a
dramatic dichotomy in T helper 1 versus T helper 2 subset expansion leading to protection …

Symptoms of human leishmaniasis range from subclinical to extensive systemic disease
with splenomegaly, hepatomegaly, skin lesions, anemia and hyperglobulinemia, but the …

American cutaneous leishmaniasis (ACL) is a vector-transmitted infectious disease with an
estimated 1.5 million new cases per year. In Brazil, ACL represents a significant public …