Shifting microglial polarization from M1 toward M2 phenotype represents a promising
therapeutic strategy for neuropathic pain (NP). Dual-specificity phosphatase-1 (DUSP1) is a …

Pain and depression are frequently co-existent in clinical practice, yet the underlying
mechanisms remain largely to be determined. Microglia activation and subsequent pro …

Activation of microglia is considered the most important component of neuroinflammation.
Microglia can adopt a pro-inflammatory (M1) or anti-inflammatory (M2) phenotype. Opioid …

Curcumin has been shown to possess strong anti-inflammatory activity in many diseases. It
has been demonstrated that the janus kinase 2 (JAK2)-signal transducer and activator of …

Spinal cord injury (SCI) is one of the main causes leading to neuropathic pain. Here, we aim
to explore the molecular mechanism and function of lncRNA PVT1 in neuropathic pain …

Previous studies have demonstrated that microRNAs (miRNAs) play important roles in the
pathogenesis of neuropathic pain. In the present study, we found that miR-32-5p was …

Background: Several studies performed thus far indicate that neuroinflammation may be one
of the mechanisms underlying the pathogenesis of neuropathic pain (NP). Autophagy, as an …

Luteolin is a flavonoid found in high concentrations in celery and green pepper, and acts as
a neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were …

Abstract Background DNA methyltransferase 1 (DNMT1) exerts imperative functions in
neuropathic pain (NP). This study explored the action of RNA interference-mediated DNMT1 …

Spinal cord injury (SCI) is a fatal and intractable disease accompanied by the comorbidity of
chronic neuropathic pain. Here, we purposed to explore the therapeutic effect and the …