DUSP1 promotes microglial polarization toward M2 phenotype in the medial prefrontal cortex of neuropathic pain rats via inhibition of MAPK pathway
X Wang, Y Jiang, J Li, Y Wang, Y Tian… - ACS chemical …, 2021 - ACS Publications
Shifting microglial polarization from M1 toward M2 phenotype represents a promising
therapeutic strategy for neuropathic pain (NP). Dual-specificity phosphatase-1 (DUSP1) is a …
therapeutic strategy for neuropathic pain (NP). Dual-specificity phosphatase-1 (DUSP1) is a …
Spared nerve injury increases the expression of microglia M1 markers in the prefrontal cortex of rats and provokes depression-like behaviors
N Xu, XH Tang, W Pan, ZM Xie, GF Zhang… - Frontiers in …, 2017 - frontiersin.org
Pain and depression are frequently co-existent in clinical practice, yet the underlying
mechanisms remain largely to be determined. Microglia activation and subsequent pro …
mechanisms remain largely to be determined. Microglia activation and subsequent pro …
Opioid receptor activation suppresses the neuroinflammatory response by promoting microglial M2 polarization
AS Mali, J Novotny - Molecular and Cellular Neuroscience, 2022 - Elsevier
Activation of microglia is considered the most important component of neuroinflammation.
Microglia can adopt a pro-inflammatory (M1) or anti-inflammatory (M2) phenotype. Opioid …
Microglia can adopt a pro-inflammatory (M1) or anti-inflammatory (M2) phenotype. Opioid …
Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling
S Liu, Q Li, MT Zhang, QL Mao-Ying, LY Hu, GC Wu… - Scientific reports, 2016 - nature.com
Curcumin has been shown to possess strong anti-inflammatory activity in many diseases. It
has been demonstrated that the janus kinase 2 (JAK2)-signal transducer and activator of …
has been demonstrated that the janus kinase 2 (JAK2)-signal transducer and activator of …
Downregulating lncRNA PVT1 relieves astrocyte overactivation induced neuropathic pain through targeting miR-186-5p/CXCL13/CXCR5 axis
P Zhang, H Sun, Z Ji - Neurochemical Research, 2021 - Springer
Spinal cord injury (SCI) is one of the main causes leading to neuropathic pain. Here, we aim
to explore the molecular mechanism and function of lncRNA PVT1 in neuropathic pain …
to explore the molecular mechanism and function of lncRNA PVT1 in neuropathic pain …
miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain
T Yan, F Zhang, C Sun, J Sun, Y Wang, X Xu… - Biochemical and …, 2018 - Elsevier
Previous studies have demonstrated that microRNAs (miRNAs) play important roles in the
pathogenesis of neuropathic pain. In the present study, we found that miR-32-5p was …
pathogenesis of neuropathic pain. In the present study, we found that miR-32-5p was …
Aspirin-triggered Resolvin D1 ameliorates activation of the NLRP3 inflammasome via induction of autophagy in a rat model of neuropathic pain
YH Wang, YR Tang, X Gao, NN Zhang, QQ Lv… - Frontiers in …, 2023 - frontiersin.org
Background: Several studies performed thus far indicate that neuroinflammation may be one
of the mechanisms underlying the pathogenesis of neuropathic pain (NP). Autophagy, as an …
of the mechanisms underlying the pathogenesis of neuropathic pain (NP). Autophagy, as an …
PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4
W Bi, K Bao, X Zhou, Y Deng, X Li, J Zhang… - Journal of …, 2023 - Springer
Luteolin is a flavonoid found in high concentrations in celery and green pepper, and acts as
a neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were …
a neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were …
RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization
Y Tan, Z Wang, T Liu, P Gao, S Xu, L Tan - BMC neurology, 2022 - Springer
Abstract Background DNA methyltransferase 1 (DNMT1) exerts imperative functions in
neuropathic pain (NP). This study explored the action of RNA interference-mediated DNMT1 …
neuropathic pain (NP). This study explored the action of RNA interference-mediated DNMT1 …
Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats
L Yang, X Gao, D Tian, W Yang, S Xue, Z Cao… - Experimental …, 2023 - Elsevier
Spinal cord injury (SCI) is a fatal and intractable disease accompanied by the comorbidity of
chronic neuropathic pain. Here, we purposed to explore the therapeutic effect and the …
chronic neuropathic pain. Here, we purposed to explore the therapeutic effect and the …
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