[HTML][HTML] Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage
Y Yang, H Ding, C Yang, J Wu, Y Bao, S Lan… - Frontiers in …, 2023 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by
dysfunctional inflammatory response. However, no effective therapeutic options have been …
dysfunctional inflammatory response. However, no effective therapeutic options have been …
[HTML][HTML] Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia
Background Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia
are activated and polarized to either the pro-inflammatory M1 phenotype or anti …
are activated and polarized to either the pro-inflammatory M1 phenotype or anti …
[HTML][HTML] SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage
DY Xia, JL Yuan, XC Jiang, M Qi, NS Lai… - Frontiers in …, 2021 - frontiersin.org
Mounting evidence has suggested that modulating microglia polarization from pro-
inflammatory M1 phenotype to anti-inflammatory M2 state might be a potential therapeutic …
inflammatory M1 phenotype to anti-inflammatory M2 state might be a potential therapeutic …
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis
P Wang, Y Zhao, Y Li, J Wu, S Yu, J Zhu, L Li, Y Zhao - Neuroscience, 2019 - Elsevier
Abstract Sestrin2 (Sesn2) is a stress response protein which expresses neuroprotective
characteristics in some neurodegenerative disorders. However, the impact of Sesn2 on the …
characteristics in some neurodegenerative disorders. However, the impact of Sesn2 on the …
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling
X Liu, M Li, J Zhu, W Huang… - Human & Experimental …, 2021 - journals.sagepub.com
Sestrin2 (SESN2) is stress-inducible protein that confers cytoprotective effects against
various noxious stimuli. Accumulating evidence has documented that SESN2 has potent anti …
various noxious stimuli. Accumulating evidence has documented that SESN2 has potent anti …
Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage
ZV Zheng, J Chen, H Lyu, SYE Lam, G Lu… - Stroke and Vascular …, 2022 - svn.bmj.com
Background and purpose Signal transducer and activator of transcription 3 (STAT3) may
contribute to the proinflammation in the central nervous system diseases by modulating the …
contribute to the proinflammation in the central nervous system diseases by modulating the …
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke …
Y Li, J Wu, S Yu, J Zhu, Y Zhou, P Wang, L Li, Y Zhao - Brain Research, 2020 - Elsevier
Aims The lack of effective treatments for ischemic stroke is concerning. Here, we aimed to
examine the protective effects of sestrin2 in ischemic stroke and determine the mechanism …
examine the protective effects of sestrin2 in ischemic stroke and determine the mechanism …
[HTML][HTML] Sestrin2 silencing exacerbates cerebral ischemia/reperfusion injury by decreasing mitochondrial biogenesis through the AMPK/PGC-1α pathway in rats
L Li, L Xiao, Y Hou, Q He, J Zhu, Y Li, J Wu, J Zhao… - Scientific Reports, 2016 - nature.com
Abstract Sestrin2 (Sesn2) exerts neuroprotective properties in some neurodegenerative
diseases. However, the role of Sesn2 in stroke is unclear. The AMP-activated protein …
diseases. However, the role of Sesn2 in stroke is unclear. The AMP-activated protein …
MFG-E8 attenuates inflammation in subarachnoid hemorrhage by driving microglial M2 polarization
YY Gao, T Tao, D Wu, Z Zhuang, Y Lu, LY Wu… - Experimental …, 2021 - Elsevier
Increasing evidence suggests that microglial polarization plays an important role in the
pathological processes of neuroinflammation following subarachnoid hemorrhage (SAH) …
pathological processes of neuroinflammation following subarachnoid hemorrhage (SAH) …
Elevating sestrin2 attenuates endoplasmic reticulum stress and improves functional recovery through autophagy activation after spinal cord injury
Y Li, J Zhang, K Zhou, L Xie, G Xiang, M Fang… - Cell Biology and …, 2021 - Springer
Spinal cord injury (SCI) is a devastating neurological trauma that causes losses of motor and
sensory function. Sestrin2, also known as hypoxia inducible gene 95, is emerging as a …
sensory function. Sestrin2, also known as hypoxia inducible gene 95, is emerging as a …