Safety, pharmacodynamics, and blood pressure effects of ALN-AGT, an RNA interference therapeutic targeting angiotensinogen, in a randomized single ascending …
SA Huang, J Taubel, G Fiore, P Dewland… - Journal of …, 2021 - journals.lww.com
Objective: Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides and plays
a key role in hypertension pathogenesis. We evaluated the effect of ALN-AGT, a …
a key role in hypertension pathogenesis. We evaluated the effect of ALN-AGT, a …
SAFETY, PHARMACODYNAMICS, AND BLOOD PRESSURE EFFECTS OF ALN-AGT, AN RNA INTERFERENCE THERAPEUTIC TARGETING ANGIOTENSINOGEN …
SA Huang, J Taubel, G Fiore, P Dewland… - Journal of …, 2021 - journals.lww.com
Objective: Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides and plays
a key role in hypertension pathogenesis. We evaluated the effect of ALN-AGT, a …
a key role in hypertension pathogenesis. We evaluated the effect of ALN-AGT, a …
[PDF][PDF] Safety, Pharmacodynamics, and Blood Pressure Effects of ALN-AGT, an RNA Interference Therapeutic Targeting Angiotensinogen, in a Randomized Single …
SA Huang, J Taubel, G Fiore, DJ Webb, GL Bakris… - capella.alnylam.com
Placebo 28 28 28 28 27 17 25 27 28 11 1 0 0 0 10 mg 8 8 8 8 8 8 8 8 8 5 2 1 1 1 25 mg 8 8 8
8 8 8 8 8 8 8 6 6 1 0 50 mg 8 8 8 8 8 8 8 7 7 7 4 2 0 0 100 mg 8 7 8 8 8 8 8 8 7 7 6 5 0 0 200 …
8 8 8 8 8 8 8 6 6 1 0 50 mg 8 8 8 8 8 8 8 7 7 7 4 2 0 0 100 mg 8 7 8 8 8 8 8 8 7 7 6 5 0 0 200 …