Understanding immunological origins of atopic dermatitis through multi‐omic analysis

R Beheshti, S Halstead, D McKeone… - Pediatric Allergy and …, 2022 - Wiley Online Library
Background The pathophysiology of atopic dermatitis (AD) is multifactorial, impacted by
individual medical, demographic, environmental, and immunologic factors. This study used …

Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity

J Gupta, E Grube, MB Ericksen, MD Stevenson… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Recent genetic evidence supports that an underlying defect in skin barrier
function contributes to the pathogenesis of atopic dermatitis (AD). The integrity of the skin …

Neuro‐mediators as predictors of paediatric atopic dermatitis

IJ Wang, WS Hsieh, YL Guo, SH Jee… - Clinical & …, 2008 - Wiley Online Library
Background Attempts to identify predictors of atopic dermatitis (AD) have focused on genetic
and immunologic factors. However, the role of neuro‐mediators remains to be elucidated …

A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis

L Hulshof, DP Hack, QCJ Hasnoe… - British journal of …, 2019 - academic.oup.com
Background Atopic dermatitis (AD) affects children of all skin types. Most research has
focused on light skin types. Studies investigating biomarkers in people with AD with dark …

Various diagnostic criteria for atopic dermatitis (AD): A proposal of R eliable E stimation of A topic D ermatitis in C hildhood (REACH) criteria, a novel questionnaire …

SC Lee… - The Journal of …, 2016 - Wiley Online Library
Atopic dermatitis (AD) is a heterogeneous disease that manifests with a wide variety of
clinical symptoms and signs. Due to the lack of definitive biomarkers for AD, it is very difficult …

A short period of breastfeeding in infancy, excessive house cleaning, absence of older sibling, and passive smoking are related to more severe atopic dermatitis in …

M Fotopoulou, M Iordanidou, E Vasileiou… - European Journal of …, 2018 - Springer
Background Atopic dermatitis (AD) is one of the most common, chronic or chronically
relapsing inflammatory skin diseases that affect children. Multiple genetic and environmental …

[HTML][HTML] Reduced skin microbiome diversity in infancy is associated with increased risk of atopic dermatitis in high-risk children

AS Halling, BG Fritz, T Gerner, MR Rinnov… - Journal of Investigative …, 2023 - Elsevier
It is currently unknown whether alterations in the skin microbiome exist before development
of atopic dermatitis (AD). In this prospective Danish birth cohort of 300 children, we …

[HTML][HTML] Introduction of the reliable estimation of atopic dermatitis in childhood: novel, diagnostic criteria for childhood atopic dermatitis

SC Lee, JM Bae, HJ Lee, HJ Kim… - Allergy, Asthma & …, 2016 - synapse.koreamed.org
Purpose Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been
proposed to detect the major group of AD with flexural dermatitis. We aimed to develop …

Nasal and skin microbiomes are associated with disease severity in paediatric atopic dermatitis

JEE Totté, LM Pardo, KB Fieten, MC Vos… - British Journal of …, 2019 - academic.oup.com
Background Alterations of the skin microbiome have been associated with atopic dermatitis
(AD) and its severity. The nasal microbiome in relation to AD severity is less well studied …

It looks like childhood eczema but is it?

CG Mortz, K Brockow… - Clinical & …, 2019 - Wiley Online Library
In childhood, the most common type of eczema/dermatitis is atopic dermatitis, which occurs
in up to 25% of children world‐wide. However, the diagnosis may sometimes be challenging …