Importance Angiotensinogen is the most upstream precursor of the renin–angiotensin–
aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an …

Background Angiotensinogen is the sole precursor of angiotensin peptides and has a key
role in the pathogenesis of hypertension. Zilebesiran, an investigational RNA interference …

Safety and Tolerability of Zilebesiran, an RNA Interference Therapeutic Targeting Hepatic
Angiotensinogen Synthesis, in Obese Pa Page 1 1 #AHA23 SUSTAINED BLOOD PRESSURE …

Hypertension remains the leading cause of cardiovascular disease and premature death
globally, affecting half of US adults. A high proportion of hypertensive patients exhibit …

Introduction Hypertension is the main global risk factor for cardiovascular disease. Despite
this, less than half of treated hypertensive patients are controlled. One reason for this is …

Background: Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides and
plays a key role in hypertension pathogenesis. We evaluated the effect of ALN-AGT01, a …

Objective: Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides and plays
a key role in hypertension pathogenesis. We evaluated the effect of ALN-AGT, a …

Hypertension is an extremely common noncom-municable condition affecting an estimated
1.3 billion adults (aged 30–79 years) worldwide and with a prevalence that has doubled …

Introduction: ALN-AGT, a subcutaneous (SC) investigational RNA interference therapeutic
targeting hepatic angiotensinogen (AGT) synthesis, is being evaluated as a novel treatment …

Targeting angiotensinogen with RNA-based therapeutics is a promising new tool to treat
hypertension and diseases beyond. Their long-lasting effects are particularly exciting, and if …