Objectives β-blockers are widely used and effective for treating hypertension, acute
myocardial infarction (MI) and heart failure, but they present side-effects mainly due to …

Background Spironolactone is effective at reducing blood pressure in patients with
uncontrolled resistant hypertension. However, the use of spironolactone in patients with …

Importance Sustained reductions in low-density lipoprotein cholesterol (LDL-C) with lipid-
lowering therapies that require frequent dosing are reliant on patient adherence, and poor …

Abstract Aims Small-interfering RNA (siRNA)-based targeting of proprotein convertase
subtilisin/kexin type 9 (PCSK9) represents a novel therapeutic approach that may provide a …

The objective of this study was to evaluate ocular tolerance, safety, and effect on intraocular
pressure (IOP) of a topically administered small interfering RNA; SYL040012, on healthy …

Uncontrolled hypertension is an important contributor to cardiovascular disease. Despite the
armamentarium of antihypertensive treatments, there remains a need for novel agents …

Importance Lipoprotein (a)(Lp [a]) is an important risk factor for atherothrombotic
cardiovascular disease and aortic stenosis, for which there are no treatments approved by …

Although significant advances have been made in the therapeutic blockade of the renin–
angiotensin–aldosterone system (RAAS) using angiotensin-converting enzyme (ACE) …

Background: We conducted a meta-analysis to summarize all available evidence from
randomized controlled trial studies regarding the clinical efficacy and safety of …

Novel bio-therapeutic agents that harness the properties of small, non-coding nucleic acids
hold great promise for clinical applications. These include antisense oligonucleotides that …