Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms

A Joutel, H Chabriat - Clinical Science, 2017 - portlandpress.com
Cerebral small vessel diseases (SVDs) are a leading cause of age and hypertension-related
stroke and dementia. The salient features of SVDs visible on conventional brain magnetic …

Understanding the role of the perivascular space in cerebral small vessel disease

R Brown, H Benveniste, SE Black… - Cardiovascular …, 2018 - academic.oup.com
Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Cerebral small vessel disease, hypertension, and vascular contributions to cognitive impairment and dementia

AH Hainsworth, HS Markus, JA Schneider - Hypertension, 2024 - Am Heart Assoc
Hypertension-associated cerebral small vessel disease is a common finding in older people.
Strongly associated with age and hypertension, small vessel disease is found at autopsy in …

Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease

PR Holland, JL Searcy, N Salvadores… - Journal of Cerebral …, 2015 - journals.sagepub.com
Cerebral small vessel disease (SVD) is a major cause of age-related cognitive impairment
and dementia. The pathophysiology of SVD is not well understood and is hampered by a …

Contributions of aging to cerebral small vessel disease

TM De Silva, FM Faraci - Annual review of physiology, 2020 - annualreviews.org
Cerebral small vessel disease (SVD) is characterized by changes in the pial and
parenchymal microcirculations. SVD produces reductions in cerebral blood flow and …

[HTML][HTML] An integrated view on vascular dysfunction in Alzheimer's disease

J Klohs - Neurodegenerative Diseases, 2020 - karger.com
Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …

[HTML][HTML] Quantifying blood-brain barrier leakage in small vessel disease: review and consensus recommendations

MJ Thrippleton, WH Backes, S Sourbron… - Alzheimer's & …, 2019 - Elsevier
Cerebral small vessel disease (cSVD) comprises pathological processes of the small
vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or …

The contribution of small vessel disease to neurodegeneration: focus on Alzheimer's disease, Parkinson's disease and multiple sclerosis

F Paolini Paoletti, S Simoni, L Parnetti… - International journal of …, 2021 - mdpi.com
Brain small vessel disease (SVD) refers to a variety of structural and functional changes
affecting small arteries and micro vessels, and manifesting as white matter changes …

A study on the pathogenesis of vascular cognitive impairment and dementia: the chronic cerebral hypoperfusion hypothesis

W Yu, Y Li, J Hu, J Wu, Y Huang - Journal of clinical medicine, 2022 - mdpi.com
The pathogenic mechanisms underlying vascular cognitive impairment and dementia
(VCID) remain controversial due to the heterogeneity of vascular causes and complexity of …

[HTML][HTML] Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: a systematic review and meta-analysis

SP Rensma, TT van Sloten, LJ Launer… - Neuroscience & …, 2018 - Elsevier
MRI features of cerebral small vessel disease (CSVD), ie white matter hyperintensities,
lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with …