Co-crystallization is a promising strategy to enhance the water solubility and bioavailability
of active pharmaceutical ingredients (APIs). Once possible coformers have been identified …

The purpose of this work is to increase the efficiency of the cocrystal formation process by
thermodynamic modeling using perturbed-chain statistical associating fluid theory (PC …

The formulation of active pharmaceutical ingredients (APIs) as pharmaceutical co-crystals
(CCs) is a promising way to overcome the poor aqueous solubility and therewith poor …

The solubility of pharmaceutical cocrystals in aqueous solution is influenced by pH-
dependent dissociation and salt formation which complicates the design of cocrystal …

In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were
predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes …

Controlling the physical properties of solid forms for active pharmaceutical ingredients (APIs)
through cocrystallization is an important part of drug product development. However, it is …

Recently, the co-crystallization of pharmaceutical drugs is gaining consideration because it
is an environmentally friendly and potentially effective technique to improve the solubility …

The poor aqueous solubility of many modern active pharmaceutical ingredients (APIs) can
severely limit bioavailability. Cocrystals are emerging as a promising means of overcoming …

Co-crystallization is known as a product formulation technology, but it can also be used as a
tool to solve crystallization problems. Product removal by co-crystallization in fermentations …

Co-crystals have garnered increasing interest in recent years as a beneficial approach to
improving the solubility of poorly water soluble active pharmaceutical ingredients (APIs) …