Sex differences in training-induced activity of the ubiquitin proteasome system in the dorsal hippocampus and medial prefrontal cortex of male and female mice
SB Beamish, KS Gross, MKM Anderson… - Learning & …, 2022 - learnmem.cshlp.org
The ubiquitin proteasome system (UPS) is a primary mechanism through which proteins are
degraded in cells. UPS activity in the dorsal hippocampus (DH) is necessary for multiple …
degraded in cells. UPS activity in the dorsal hippocampus (DH) is necessary for multiple …
Distinct subcellular changes in proteasome activity and linkage-specific protein polyubiquitination in the amygdala during the consolidation and reconsolidation of a …
SA Orsi, RK Devulapalli, JL Nelsen, T McFadden… - Neurobiology of learning …, 2019 - Elsevier
Numerous studies have supported a critical role for the ubiquitin-proteasome system (UPS)
in the memory consolidation and reconsolidation processes. The protein targets and …
in the memory consolidation and reconsolidation processes. The protein targets and …
Age-related memory deficits are associated with changes in protein degradation in brain regions critical for trace fear conditioning
BN Dulka, SE Pullins, PK Cullen, JR Moyer Jr… - Neurobiology of …, 2020 - Elsevier
Brain aging is accompanied by an accumulation of damaged proteins, which results from
deterioration of cellular quality control mechanisms and decreased protein degradation. The …
deterioration of cellular quality control mechanisms and decreased protein degradation. The …
Proteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala
Females are more likely than males to develop post-traumatic stress disorder (PTSD).
However, the neurobiological mechanisms responsible for these sex differences remain …
However, the neurobiological mechanisms responsible for these sex differences remain …
[HTML][HTML] Age-related memory impairment and sex-specific alterations in phosphorylation of the Rpt6 proteasome subunit and polyubiquitination in the basolateral …
Aging is marked by an accumulation of damaged and modified brain proteins, and the
ubiquitin-proteasome system (UPS) is important for cellular protein degradation. Recent …
ubiquitin-proteasome system (UPS) is important for cellular protein degradation. Recent …
[HTML][HTML] Sex-specific linear polyubiquitination is a critical regulator of contextual fear memory formation
M Musaus, K Farrell, S Navabpour, WK Ray… - Frontiers in Behavioral …, 2021 - frontiersin.org
Strong evidence supports that protein ubiquitination is a critical regulator of fear memory
formation. However, as this work has focused on protein degradation, it is currently unknown …
formation. However, as this work has focused on protein degradation, it is currently unknown …
The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation
Numerous studies have suggested a role for ubiquitin–proteasome-mediated protein
degradation in learning-dependent synaptic plasticity; however, very little is known about …
degradation in learning-dependent synaptic plasticity; however, very little is known about …
[HTML][HTML] Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus
MB Patrick, NJ Preveza, SE Kincaid, G Setenet… - Brain Research …, 2024 - Elsevier
The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells
and dysregulation of the UPS has been implicated in the pathophysiology of numerous …
and dysregulation of the UPS has been implicated in the pathophysiology of numerous …
Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation
R Devulapalli, N Jones, K Farrell, M Musaus… - Neurobiology of learning …, 2021 - Elsevier
Over the last decade, strong evidence has emerged that protein degradation mediated by
the ubiquitin-proteasome system is critical for fear memory formation in the amygdala …
the ubiquitin-proteasome system is critical for fear memory formation in the amygdala …
The epigenetic role of proteasome subunit RPT6 during memory formation in female rats
K Farrell, A Auerbach, M Musaus… - Learning & …, 2022 - learnmem.cshlp.org
Reports of sex differences in the neurobiology of memory formation are becoming more
prevalent. Despite this, much remains unknown about the role of sex in this process. We …
prevalent. Despite this, much remains unknown about the role of sex in this process. We …