The delicate skin of preterm infants: Barrier function, immune-microbiome interaction, and clinical implications

J Marissen, M Gomez de Agüero, P Chandorkar… - Neonatology, 2023 - karger.com
The skin of preterm infants is a delicate organ with critical structural and functional
differences as compared to term born infants. Unique features contribute to an increased …

Development of the cutaneous microbiome in the preterm infant: A prospective longitudinal study

M Pammi, JL O'Brien, NJ Ajami, MC Wong… - PloS one, 2017 - journals.plos.org
Background Neonatal sepsis in preterm infants is often due to organisms that colonize the
skin including Staphylococcus spp. and Candida spp. Development and maturation of the …

Early life host-microbe interactions in skin

LR Dwyer, TC Scharschmidt - Cell host & microbe, 2022 - cell.com
Our skin is the interface through which we mediate lifelong interactions with our surrounding
environment. Initial development of the skin's epidermis, adnexal structures, and barrier …

[HTML][HTML] An update on the current understanding of the infant skin microbiome and research challenges

IR Serghiou, MA Webber, LJ Hall - Current Opinion in Microbiology, 2023 - Elsevier
Highlights•Identification of the main factors that affect the infant skin microbiome.•How infant
skin microbiome profiles are impacted by external factors and disease.•Knowledge gaps for …

The infantile cutaneous microbiome: A review

JJ Schoch, RL Monir, KG Satcher, J Harris… - Pediatric …, 2019 - Wiley Online Library
Recent focus on the neonatal intestinal microbiome has advanced our knowledge of the
complex interplay between the intestinal barrier, the developing immune system, and …

Evolving concepts of neonatal skin

CC Coughlin, A Taïeb - Pediatric dermatology, 2014 - Wiley Online Library
Evolving Concepts of Neonatal Skin Page 1 Evolving Concepts of Neonatal Skin Carrie C.
Coughlin, MD,* and Alain Taıeb, MD, Ph.D.† *Division of Dermatology, Department of Medicine …

Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin

MO Visscher, AN Carr, J Winget, T Huggins… - Pediatric …, 2021 - nature.com
Background The objective of this study was to measure skin characteristics in premature
(PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1 …

Neonatal sepsis and the skin microbiome

IS Harrison, RL Monir, J Neu, JJ Schoch - Journal of Perinatology, 2022 - nature.com
Neonatal sepsis is a major cause of morbidity and mortality in preterm infants. Preterm and
very low birth weight infants are particularly susceptible to sepsis due to their immature skin …

Early development of the skin microbiome: therapeutic opportunities

BW Casterline, AS Paller - Pediatric research, 2021 - nature.com
As human skin hosts a diverse microbiota in health and disease, there is an emerging
consensus that dysregulated interactions between host and microbiome may contribute to …

[HTML][HTML] Skin barrier immunology from early life to adulthood

A Trompette, ND Ubags - Mucosal Immunology, 2023 - Elsevier
Our skin has a unique barrier function, which is imperative for the body's protection against
external pathogens and environmental insults. Although interacting closely and sharing …