[HTML][HTML] Transposable elements in human cancer: causes and consequences of deregulation

SL Anwar, W Wulaningsih, U Lehmann - International journal of molecular …, 2017 - mdpi.com
Transposable elements (TEs) comprise nearly half of the human genome and play an
essential role in the maintenance of genomic stability, chromosomal architecture, and …

Human population-specific gene expression and transcriptional network modification with polymorphic transposable elements

L Wang, L Rishishwar, L Mariño-Ramírez… - Nucleic Acids …, 2017 - academic.oup.com
Transposable element (TE) derived sequences are known to contribute to the regulation of
the human genome. The majority of known TE-derived regulatory sequences correspond to …

RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements

J Brosius - Gene, 1999 - Elsevier
While the significance of middle repetitive elements had been neglected for a long time,
there are again tendencies to ascribe most members of a given middle repetitive sequence …

Transposable elements donate lineage-specific regulatory sequences to host genomes

L Marino-Ramirez, KC Lewis, D Landsman… - … and genome research, 2005 - karger.com
The evolutionary implications of transposable element (TE) influences on gene regulation
are explored here. An historical perspective is presented to underscore the importance of TE …

[HTML][HTML] Mammalian-wide interspersed repeat (MIR)-derived enhancers and the regulation of human gene expression

D Jjingo, AB Conley, J Wang, L Mariño-Ramírez… - Mobile DNA, 2014 - Springer
Background Mammalian-wide interspersed repeats (MIRs) are the most ancient family of
transposable elements (TEs) in the human genome. The deep conservation of MIRs initially …

Exaptation of Transposable Elements into Novel Cis-Regulatory Elements: Is the Evidence Always Strong?

FSJ de Souza, LF Franchini… - Molecular biology and …, 2013 - academic.oup.com
Transposable elements (TEs) are mobile genetic sequences that can jump around the
genome from one location to another, behaving as genomic parasites. TEs have been …

The impact of transposable elements on mammalian development

JL Garcia-Perez, TJ Widmann, IR Adams - Development, 2016 - journals.biologists.com
Despite often being classified as selfish or junk DNA, transposable elements (TEs) are a
group of abundant genetic sequences that have a significant impact on mammalian …

The 3′ ends of tRNA-derived short interspersed repetitive elements are derived from the 3′ ends of long interspersed repetitive elements

K Ohshima, M Hamada, Y Terai… - Molecular and cellular …, 1996 - Am Soc Microbiol
Short interspersed repetitive elements (SINEs) are a type of retroposon, being members of a
class of informational molecules that are amplified via cDNA intermediates and flow back …

Widespread contribution of transposable elements to the innovation of gene regulatory networks

V Sundaram, Y Cheng, Z Ma, D Li, X Xing… - Genome …, 2014 - genome.cshlp.org
Transposable elements (TEs) have been shown to contain functional binding sites for
certain transcription factors (TFs). However, the extent to which TEs contribute to the …

Transposable elements as genetic regulatory substrates in early development

WD Gifford, SL Pfaff, TS Macfarlan - Trends in cell biology, 2013 - cell.com
The abundance and ancient origins of transposable elements (TEs) in eukaryotic genomes
has spawned research into the potential symbiotic relationship between these elements and …