Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes
V Sundaram, J Wysocka - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded
within the vast non-coding genomic space and recognized by the transcription factors in a …
within the vast non-coding genomic space and recognized by the transcription factors in a …
Transposable elements in the mammalian embryo: pioneers surviving through stealth and service
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary
time, TE insertions can supply new promoter, enhancer, and insulator elements to protein …
time, TE insertions can supply new promoter, enhancer, and insulator elements to protein …
Transposable element exaptation into regulatory regions is rare, influenced by evolutionary age, and subject to pleiotropic constraints
CN Simonti, M Pavličev, JA Capra - Molecular Biology and …, 2017 - academic.oup.com
Transposable element (TE)-derived sequences make up approximately half of most
mammalian genomes, and many TEs have been co-opted into gene regulatory elements …
mammalian genomes, and many TEs have been co-opted into gene regulatory elements …
Role of transposable elements in gene regulation in the human genome
Transposable elements (TEs), also known as mobile elements (MEs), are interspersed
repeats that constitute a major fraction of the genomes of higher organisms. As one of their …
repeats that constitute a major fraction of the genomes of higher organisms. As one of their …
Roles of transposable elements in the regulation of mammalian transcription
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …
contain sequences capable of recruiting the host transcription machinery, which they use to …
Exaptation of Transposable Elements into Novel Cis-Regulatory Elements: Is the Evidence Always Strong?
FSJ de Souza, LF Franchini… - Molecular biology and …, 2013 - academic.oup.com
Transposable elements (TEs) are mobile genetic sequences that can jump around the
genome from one location to another, behaving as genomic parasites. TEs have been …
genome from one location to another, behaving as genomic parasites. TEs have been …
Transposable elements as genetic regulatory substrates in early development
WD Gifford, SL Pfaff, TS Macfarlan - Trends in cell biology, 2013 - cell.com
The abundance and ancient origins of transposable elements (TEs) in eukaryotic genomes
has spawned research into the potential symbiotic relationship between these elements and …
has spawned research into the potential symbiotic relationship between these elements and …
Transposable elements generate regulatory novelty in a tissue-specific fashion
M Trizzino, A Kapusta, CD Brown - BMC genomics, 2018 - Springer
Background Transposable elements (TE) are an important source of evolutionary novelty in
gene regulation. However, the mechanisms by which TEs contribute to gene expression are …
gene regulation. However, the mechanisms by which TEs contribute to gene expression are …
The developmental control of transposable elements and the evolution of higher species
M Friedli, D Trono - Annual review of cell and developmental …, 2015 - annualreviews.org
Transposable elements (TEs) account for at least 50% of the human genome. They
constitute essential motors of evolution through their ability to modify genomic architecture …
constitute essential motors of evolution through their ability to modify genomic architecture …
Transposable elements donate lineage-specific regulatory sequences to host genomes
L Marino-Ramirez, KC Lewis, D Landsman… - … and genome research, 2005 - karger.com
The evolutionary implications of transposable element (TE) influences on gene regulation
are explored here. An historical perspective is presented to underscore the importance of TE …
are explored here. An historical perspective is presented to underscore the importance of TE …
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