Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes

V Sundaram, J Wysocka - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded
within the vast non-coding genomic space and recognized by the transcription factors in a …

Transposable elements in the mammalian embryo: pioneers surviving through stealth and service

P Gerdes, SR Richardson, DL Mager, GJ Faulkner - Genome biology, 2016 - Springer
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary
time, TE insertions can supply new promoter, enhancer, and insulator elements to protein …

Transposable element exaptation into regulatory regions is rare, influenced by evolutionary age, and subject to pleiotropic constraints

CN Simonti, M Pavličev, JA Capra - Molecular Biology and …, 2017 - academic.oup.com
Transposable element (TE)-derived sequences make up approximately half of most
mammalian genomes, and many TEs have been co-opted into gene regulatory elements …

Role of transposable elements in gene regulation in the human genome

A Ali, K Han, P Liang - Life, 2021 - mdpi.com
Transposable elements (TEs), also known as mobile elements (MEs), are interspersed
repeats that constitute a major fraction of the genomes of higher organisms. As one of their …

Roles of transposable elements in the regulation of mammalian transcription

R Fueyo, J Judd, C Feschotte, J Wysocka - Nature reviews Molecular …, 2022 - nature.com
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Exaptation of Transposable Elements into Novel Cis-Regulatory Elements: Is the Evidence Always Strong?

FSJ de Souza, LF Franchini… - Molecular biology and …, 2013 - academic.oup.com
Transposable elements (TEs) are mobile genetic sequences that can jump around the
genome from one location to another, behaving as genomic parasites. TEs have been …

Transposable elements as genetic regulatory substrates in early development

WD Gifford, SL Pfaff, TS Macfarlan - Trends in cell biology, 2013 - cell.com
The abundance and ancient origins of transposable elements (TEs) in eukaryotic genomes
has spawned research into the potential symbiotic relationship between these elements and …

Transposable elements generate regulatory novelty in a tissue-specific fashion

M Trizzino, A Kapusta, CD Brown - BMC genomics, 2018 - Springer
Background Transposable elements (TE) are an important source of evolutionary novelty in
gene regulation. However, the mechanisms by which TEs contribute to gene expression are …

The developmental control of transposable elements and the evolution of higher species

M Friedli, D Trono - Annual review of cell and developmental …, 2015 - annualreviews.org
Transposable elements (TEs) account for at least 50% of the human genome. They
constitute essential motors of evolution through their ability to modify genomic architecture …

Transposable elements donate lineage-specific regulatory sequences to host genomes

L Marino-Ramirez, KC Lewis, D Landsman… - … and genome research, 2005 - karger.com
The evolutionary implications of transposable element (TE) influences on gene regulation
are explored here. An historical perspective is presented to underscore the importance of TE …