Background Hypertension (HTN) and diabetes mellitus (DM) are highly prevalent in low-and
middle-income countries (LMIC) and a leading cause of morbidity and mortality. Recent …

Background The comparative efficacy and safety of pharmacological agents to lower blood
pressure in adults with diabetes and kidney disease remains controversial. We aimed to …

Background Primary prevention of cardiovascular disease (CVD) requires adequate control
of hypertension and diabetes. We designed and implemented pharmaceutical and healthy …

Introduction The objective of this systematic review is to investigate the effectiveness,
efficacy and safety of multiple concomitant lifestyle modification therapies for patients with …

Current European guidelines for the management of hypertension and on cardiovascular
disease prevention place the threshold for pharmacological treatment at a SBP level of 140 …

Objective: To systematically evaluate the efficacy of five commonly used blood pressure-
lowering drugs in reducing cardiovascular events among patients with nonacute …

Background This review aims to rate the quality of evidence and the strength of
recommendations in high-quality systematic reviews of non-drug therapies. Hypertensive …

Evidence from randomized trials has shown that effective treatment with blood pressure (BP)-
lowering medications reduces the risk of cardiovascular morbidity and mortality in patients …

Background We aimed to investigate whether the benefits of blood pressure-lowering drugs
are proportional to baseline cardiovascular risk, to establish whether absolute risk could be …

1392 Hypertension November 2020 to adverse events. The authors acknowledged the
quality of evidence supporting the benefit and adverse event outcomes as moderate and …