Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin
RD Guzy, I Stoilov, TJ Elton, RP Mecham… - American journal of …, 2015 - atsjournals.org
The pathogenesis of pulmonary fibrosis involves lung epithelial injury and aberrant
proliferation of fibroblasts, and results in progressive pulmonary scarring and declining lung …
proliferation of fibroblasts, and results in progressive pulmonary scarring and declining lung …
FAM13A as potential therapeutic target in modulating TGF-β-induced airway tissue remodeling in COPD
A Tam, P Leclair, LV Li, CX Yang, X Li… - … of Physiology-Lung …, 2021 - journals.physiology.org
Genome-wide association studies have shown that a gene variant in the Family with
sequence similarity 13, member A (FAM13A) is strongly associated with reduced lung …
sequence similarity 13, member A (FAM13A) is strongly associated with reduced lung …
Expression of fibroblast growth factor 9 in normal human lung and idiopathic pulmonary fibrosis
E Coffey, DR Newman… - Journal of Histochemistry …, 2013 - journals.sagepub.com
The fibroblast growth factor (FGF) family of signaling ligands contributes significantly to lung
development and maintenance in the adult. FGF9 is involved in control of epithelial …
development and maintenance in the adult. FGF9 is involved in control of epithelial …
A functional variant alters binding of activating protein 1 regulating expression of FGF7 gene associated with chronic obstructive pulmonary disease
X Zhang, Y Guo, J Yang, J Niu, L Du, H Li, X Li - BMC Medical Genetics, 2019 - Springer
Background Genome-wide association studies (GWASs) of a large cohort of subjects with
chronic obstructive pulmonary disease (COPD) have successfully identified multiple risk …
chronic obstructive pulmonary disease (COPD) have successfully identified multiple risk …
Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPARγ expression and suppressing inflammatory cytokine levels
J Liu, G Cai, M Li, S Fan, B Yao, W Ping… - Biochemical and …, 2018 - Elsevier
Hypoxia-induced pulmonary hypertension (HPH) is a progressive disease characterized by
a sustained, elevated pulmonary arterial pressure and vascular remodeling. The latter …
a sustained, elevated pulmonary arterial pressure and vascular remodeling. The latter …
FGF2, an immunomodulatory factor in asthma and chronic obstructive pulmonary disease (COPD)
Y Tan, Y Qiao, Z Chen, J Liu, Y Guo, T Tran… - Frontiers in cell and …, 2020 - frontiersin.org
The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF
family. It plays a role in airway remodeling associated with chronic inflammatory airway …
family. It plays a role in airway remodeling associated with chronic inflammatory airway …
Cross-talk between inflammation and fibroblast growth factor 10 during organogenesis and pathogenesis: lessons learnt from the lung and other organs
M Marega, C Chen, S Bellusci - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
The adult human lung is constantly exposed to irritants like particulate matter, toxic chemical
compounds, and biological agents (bacteria and viruses) present in the external …
compounds, and biological agents (bacteria and viruses) present in the external …
Exogenous fibroblast growth factor-10 induces cystic lung development with altered target gene expression in the presence of heparin in cultures of embryonic rat …
S Hashimoto, H Nakano, Y Suguta, S Irie, L Jianhua… - Pathobiology, 2012 - karger.com
Objectives: Signaling by fibroblast growth factor (FGF) receptor (FGFR) 2IIIb regulates
branching morphogenesis in the mammalian lung. FGFR2IIIb is primarily expressed in …
branching morphogenesis in the mammalian lung. FGFR2IIIb is primarily expressed in …
[HTML][HTML] The early and late intervention effects of collagen-binding FGF2 on elastase-induced lung injury
X Wang, X Hou, Y Zhao, R Zhao, J Dai, H Dai… - Biomedicine & …, 2023 - Elsevier
Introduction Chronic obstructive pulmonary disease (COPD) has high morbidity and
mortality, with no effective treatment at present. Emphysema, a major component of COPD …
mortality, with no effective treatment at present. Emphysema, a major component of COPD …
[HTML][HTML] Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
SK Ramasamy, AA Mailleux, VV Gupte, F Mata… - Developmental …, 2007 - Elsevier
The key role played by Fgf10 during early lung development is clearly illustrated in Fgf10
knockout mice, which exhibit lung agenesis. However, Fgf10 is continuously expressed …
knockout mice, which exhibit lung agenesis. However, Fgf10 is continuously expressed …