Poor inhibitory control and heightened feelings of stimulation after alcohol are two well-
established risk factors for alcohol use disorder (AUD). Although these risk factors have …

Alcohol dependence can result in long-lasting deficits to decision-making and action control.
Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for …

Alcohol use disorder (AUD) exacts a major personal, societal, and economic toll. Top-down
control from the prefrontal cortex (PFC), a critical hub for decision making, executive, and …

An implicit tenet of the alcohol use disorder (AUD) research field is that knowledge of how
alcohol interacts with the brain is critical to the development of an understanding of …

Alcohol is the most commonly abused substance among adolescents, promoting the
development of substance use disorders and compromised decision-making in adulthood …

Drug addictions including alcoholism are characterized by degradation of executive control
over behavior and increased compulsive drug seeking. These profound behavioral changes …

Loss of control over drinking is a key deficit in alcoholism causally associated with
malfunction of the medial prefrontal cortex (mPFC), but underlying molecular and cellular …

Deficits in behavioral flexibility are a hallmark of multiple psychiatric, neurological, and
substance use disorders. These deficits are often marked by decreased function of the …

The reinforcement of voluntary alcohol-seeking behavior requires dopamine-dependent
long-term synaptic plasticity in the striatum. Specifically, the long-term potentiation (LTP) of …

Alcohol use disorder is associated with altered neuron function including those in
orbitofrontal cortex (OFC) and basolateral amygdala (BLA) that send glutamatergic inputs to …