Background The medial prefrontal cortex (mPFC) inhibits impulsive and compulsive
behaviors that characterize drug abuse and dependence. Acamprosate is the leading …

The transition to alcohol use disorder (AUD) involves persistent neuroadaptations in
executive control functions primarily regulated by the medial prefrontal cortex. However, the …

Deficits in instrumental, goal-directed control, combined with the influence of drug-
associated Pavlovian-conditioned stimuli, are thought to influence the development and …

Alcohol intake remains controlled in a majority of users but becomes “compulsive,” ie,
continues despite adverse consequences, in a minority who develop alcohol addiction …

Background The medial prefrontal cortex (PFC) is crucial for regulating craving and alcohol
seeking in alcohol use disorder (AUD) patients and alcohol seeking in animal models …

Background A clinical hallmark of alcohol use disorder is persistent drinking despite
potential adverse consequences. The ventromedial prefrontal cortex (vmPFC) and …

While the ability to process fermented fruits and alcohols was once an adaptive trait that
improved nutrition and quality of life, the availability and prevalence of high potency …

Persons with alcoholism who are abstinent exhibit persistent impairments in the capacity for
response inhibition, and this form of impulsivity is significantly associated with heightened …

Alcoholism, more generically drug addiction, can be defined as a chronically relapsing
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of …

Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the
dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of …