[HTML][HTML] EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis

E Greaves, AW Horne, H Jerina, M Mikolajczak… - Scientific reports, 2017 - nature.com
Endometriosis is an incurable gynecological disorder characterized by debilitating pain and
the establishment of innervated endometriosis lesions outside the uterus. In a preclinical …

Hypothalamic-pituitary-adrenal axis responses in women with endometriosis-related chronic pelvic pain

R Ortiz, JAL Gemmill, N Sinaii, B Stegmann… - Reproductive …, 2020 - Springer
Some chronic pain conditions and comorbidities suppress the hypothalamic-pituitary-
adrenal (HPA) axis and response to dynamic testing. We measured HPA axis responses to …

[HTML][HTML] Androgens, endometriosis and pain

SF Evans, ML Hull, MR Hutchinson… - Frontiers in Reproductive …, 2021 - frontiersin.org
The intriguing relationship between androgens, endometriosis and chronic pain continues to
unfold. Determining this relationship is of crucial importance to gynecologists managing …

Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain

P Alvarez, O Bogen, JD Levine - PAIN®, 2014 - Elsevier
Endometriosis, the most common cause of chronic pelvic pain, is an estrogen-dependent
disease in which classic estrogen receptors (ERα, ERβ) play an important role. Although …

[HTML][HTML] Pathophysiology of pain in patients with peritoneal endometriosis

S Ferrero, VG Vellone, F Barra - Annals of translational medicine, 2019 - ncbi.nlm.nih.gov
Endometriosis is a chronic disease characterized by the presence of hormone-responsive
endometriotic glands and stroma outside the uterus that affect at least 4% of reproductive …

[HTML][HTML] Mechanisms of peripheral sensitization in endometriosis patients with peritoneal lesions and acyclical pain

RV Velho, J Sehouli, S Mechsner - Archives of Gynecology and Obstetrics, 2023 - Springer
Purpose Endometriosis (EM) is one of the most frequent differential diagnoses concerning
chronic pelvic pain. Women under hormonal therapy (HT) often benefit from it but sometimes …

Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis

F Barra, C Scala, S Ferrero - Expert opinion on drug metabolism & …, 2018 - Taylor & Francis
Introduction: Endometriosis is a chronic estrogen and progestogen responsive inflammatory
disease associated with pain symptoms and infertility. The medical therapy of endometriosis …

A proposed platform for phenotyping endometriosis-associated pain: unifying peripheral and central pain mechanisms

PJ Yong, C Williams, MA Bedaiwy, C Allaire - Current Obstetrics and …, 2020 - Springer
Abstract Purpose of the Review Endometriosis is defined by a finding of ectopic endometrial
glands/stroma, and is characterized by a wide variability in pain symptoms. The goal of this …

Endometriosis and pelvic pain

DL Olive, RE Blackwell, AB Copperman - Chronic Pelvic Pain: Evaluation …, 1998 - Springer
Endometriosis is a common disorder confronting any physician that cares for reproductive-
age women; however, it is among the most enigmatic of gynecologic disorders. Among the …

Inflammation and nerve fiber interaction in endometriotic pain

BD McKinnon, D Bertschi, NA Bersinger… - Trends in Endocrinology …, 2015 - cell.com
Endometriosis is an extremely prevalent estrogen-dependent condition characterized by the
growth of ectopic endometrial tissue outside the uterine cavity, and is often presented with …