Atherosclerosis is an important pathological basis of several cardiovascular diseases and
viewed as a fundamental indicator for cardiovascular disease management. Gene therapy is …

Cardiovascular disease (CVD) accounts for almost half of all deaths worldwide and has now
surpassed infectious disease as the leading cause of death and disability in developing …

Cardiovascular disease (CVD) has overtaken infectious illnesses as the leading cause of
mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis …

Atherosclerosis treatments by gene regulation are garnering attention, yet delivery of gene
cargoes to atherosclerotic plaques remains inefficient. Here, we demonstrate that assembly …

Highlights•Nucleic acid-based technologies are emerging therapies for atherosclerosis.•
Antisense oligonucleotides, siRNAs, microRNAs and decoys can modulate lipids.•We …

Abstract Purpose of Review Atherosclerosis is characterized by accumulation of lipids and
chronic inflammation in medium size to large arteries. Recently, RNA-based antisense …

Nucleic acid-based therapies are being rapidly developed for prevention and management
of cardiovascular diseases (CVD). Remarkable advancements have been achieved in the …

Gene therapy is a technique that rectifies defective or abnormal genes by introducing
exogenous genes into target cells to cure the disease. Although gene therapy has gained …

This Review examines the state-of-the-art in the delivery of nucleic acid therapies that are
directed to the vascular endothelium. First, we review the most important homeostatic …

Angiogenesis is naturally balanced by many pro-and anti-angiogenic factors while an
imbalance of these factors leads to aberrant angiogenesis, which is closely associated with …