The renin-angiotensin-aldosterone system (RAAS) is a well-defined pathway playing a key
role in maintaining circulatory homeostasis. Abnormal activation of RAAS contributes to …

This review discusses recent developments in the use of non-coding RNAs (ncRNAs) for the
regulation of therapeutically relevant genes, with special focus on applications for the …

Targeting angiotensinogen (AGT) may provide a novel approach to more optimally inhibit
the renin-angiotensin-aldosterone system pathway. Double-blind, placebo-controlled …

Small interfering RNA (siRNA) targeting liver angiotensinogen (AGT) lowers blood pressure,
but its effectiveness in hypertensive chronic kidney disease is unknown. Considering that …

Ribonucleic acid (RNA)-targeted therapeutics, including antisense oligonucleotide
technologies as well as small interfering RNAs (siRNAs), represent a new class of …

Essential hypertension is a disease with a major impact on health worldwide, thus control of
blood pressure seems to be a key component of cardiovascular disease prevention. Despite …

Atherosclerosis is an important pathological basis of several cardiovascular diseases and
viewed as a fundamental indicator for cardiovascular disease management. Gene therapy is …

The goal of gene therapy for hypertension is to provide treatment that decreases blood
pressure for much longer than can be achieved using a single dose of currently available …

Purpose of Review RNA therapeutics are a new and rapidly expanding class of drugs to
prevent or treat a wide spectrum of diseases. We discuss the defining characteristics of the …

Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a
significant global health challenge. Consequently, the development of innovative …