Long-term research on various types of RNAs has led to further understanding of diverse
mechanisms, which eventually resulted in the rapid development of RNA-based …

COVID-19 brought about the mRNA vaccine and a paradigm shift to a new mode of treating
and preventing diseases. Synthetic RNA products are a low-cost solution based on a novel …

Hypertension has become a growing public health concern worldwide. In fact, hypertension
is commonly associated with increased morbidity and mortality. Currently, oligonucleotide …

Hypertension, or high blood pressure, is a prevalent yet modifiable risk factor for
cardiovascular disease. While there are many effective treatments available to combat …

Inhibiting angiotensinogen (AGT) with an antisense oligonucleotide (ASO) might be a
promising approach to inhibit the renin–angiotensin–aldosterone system (RAAS) for the …

The renin-angiotensin-aldosterone system (RAAS) is responsible for maintaining blood
pressure and vascular tone. Modulation of the RAAS, therefore, interferes with essential …

Abstract 12 years following the discovery of the RNAi mechanism in Man, a number of RNAi
therapeutics development candidates have emerged with profiles suggesting that they could …

The conventional antihypertensive therapies including renin–angiotensin–aldosterone
system antagonists (converting enzyme inhibitors, receptor blockers, renin inhibitors, and …

Long noncoding RNAs (lncRNAs) have emerged as critical regulators of cellular functions
including maintenance of cellular homeostasis as well as the onset and progression of …

High blood pressure or hypertension is an outstanding public health problem affecting
nearly 40% of the World's adult population. Prevalence of hypertension has a strong …