High blood pressure or hypertension is an outstanding public health problem affecting
nearly 40% of the World's adult population. Prevalence of hypertension has a strong …

Purpose Endothelial cell (EC) dysfunction underlies the pathology of multiple disease
conditions including cardiovascular and pulmonary diseases. Dysfunctional ECs have a …

Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of
Familial Hypercholesterolemia | Circulation Science Volunteer Warning signs SearchSearch …

Diabetic kidney disease (DKD) is escalating and is the major cause of end stage kidney
failure. There is increasing evidence to support the role of epigenetic factors and metabolic …

Arterial hypertension is the most prevalent controllable disease world-wide. Yet, we still
need to further improve blood pressure control, deal with resistant hypertension, and we …

Objectives β-blockers are widely used and effective for treating hypertension, acute
myocardial infarction (MI) and heart failure, but they present side-effects mainly due to …

Discovered three decades ago, microRNAs (miRNAs) are now recognized as key players in
the pathophysiology of multiple human diseases, including those affecting the …

The majority of the human genome encodes non-coding RNAs (ncRNAs), species of RNA
without protein-coding potential but with powerful regulatory functions in disease onset and …

The principle of RNAi & its advantages for therapeutic application 20 years after the
discovery of RNA interference in the late 1990s [1], it is obvious that RNAi has opened novel …

RNA therapy refers to the treatment or prevention of diseases using RNA-based molecules.
The recent advent of a series of effective messenger RNA-based vaccines in response to the …