[HTML][HTML] Circuit dysfunctions of associative and sensorimotor basal ganglia loops in alcohol use disorder: insights from animal models

G Sitzia, DM Lovinger - Addiction neuroscience, 2023 - Elsevier
Abstract Persons that develop Alcohol Use Disorder (AUD) experience behavioral changes
that include compulsion to seek and take alcohol despite its negative consequences on the …

Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle

MA Doyle, A Taylor, DG Winder - 2023 - Springer
An implicit tenet of the alcohol use disorder (AUD) research field is that knowledge of how
alcohol interacts with the brain is critical to the development of an understanding of …

Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity

DC Schreiner, A Wright, ET Baltz, T Wang, C Cazares… - Cell reports, 2023 - cell.com
Alcohol use disorder (AUD) alters decision-making control over actions, but disruptions to
the responsible neural circuit mechanisms are unclear. Premotor corticostriatal circuits are …

Neurocircuitry of alcohol addiction: synthesis from animal models

GF Koob - Handbook of clinical neurology, 2014 - Elsevier
Alcoholism, more generically drug addiction, can be defined as a chronically relapsing
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of …

Neurobiological mechanisms of control in alcohol use disorder–Moving towards mechanism-based non-invasive brain stimulation treatments

F Ghin, C Beste, AK Stock - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Alcohol use disorder (AUD) is characterized by excessive habitual drinking and loss of
control over alcohol intake despite negative consequences. Both of these aspects foster …

Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits

R Renteria, ET Baltz, CM Gremel - Nature communications, 2018 - nature.com
Addiction involves a predominance of habitual control mediated through action selection
processes in dorsal striatum. Research has largely focused on neural mechanisms …

Alcohol and basal ganglia circuitry: Animal models

DM Lovinger, VA Alvarez - Neuropharmacology, 2017 - Elsevier
Brain circuits that include the cortex and basal ganglia make up the bulk of the forebrain,
and influence behaviors related to almost all aspects of affective, cognitive and sensorimotor …

Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network

N Canessa, G Basso, I Carne, P Poggi, C Gianelli - Scientific reports, 2021 - nature.com
Increased decision latency in alcohol use disorder (AUD) has been generally explained in
terms of psychomotor slowing. Recent results suggest that AUD patients' slowed decision …

Biological substrates of addiction

ME Joffe, CA Grueter, BA Grueter - … Reviews: Cognitive Science, 2014 - Wiley Online Library
This review is an introduction to addiction, the reward circuitry, and laboratory addiction
models. Addiction is a chronic disease hallmarked by a state of compulsive drug seeking …

Dissociable brain signatures of choice conflict and immediate reward preferences in alcohol use disorders

M Amlung, LH Sweet, J Acker, CL Brown… - Addiction …, 2014 - Wiley Online Library
Impulsive delayed reward discounting (DRD) is an important behavioral process in alcohol
use disorders (AUDs), reflecting incapacity to delay gratification. Recent work in …