Pharmaceutical cocrystals are formed between active pharmaceutical ingredients (APIs) and
coformers that are biologically safe. Cocrystals are of considerable relevance to the …

Co-crystal-solution phase interactions have a major impact on our ability to understand and
engineer co-crystal solubility. Recent advances in crystal engineering, in combination with …

The pharmaceutical industry needs design tools to identify greener and more resource-
efficient process routes. Current model-based solvent selection methodologies often focus …

It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening
model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be …

Two of the main questions regarding cocrystal selection and formulation development are
whether the will be stable and how fast can it dissolve the drug dose. Dissolving the drug …

The design of pharmaceutical crystals that possess different molecular components is
valuable to control pharmaceutical properties of solids without changing the covalent bonds …

There is increasing interest in cocrystal and cocrystalline salts as alternate pharmaceutical
solid forms because they provide a range of physicochemical and biopharmaceutical …

In silico screening was performed to search for binary solids in which a phenylpiperazine-
derivative drug was cocrystallized with a dicarboxylic acid. The phenylpiperazine derivative …

In the pharmaceutical industry, both company internal and regulatory authorities impose
stringent requirements on the product quality, which includes crystal size distribution, of …

The continuing research and use of co-crystallisation for separation, purification and
modification of pharmaceutical materials in multiple industrial sectors can be attributed to the …